Synthesis, aggregation and spectroscopic studies of novel water soluble metal free, zinc, copper and magnesium phthalocyanines and investigation of their anti-bacterial properties

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dc.authoridBayrak, Riza/0000-0002-0398-7694
dc.authoridBERIS, FATIH SABAN/0000-0002-0535-943X
dc.authoridAKCAY, Hakki Turker/0000-0002-8502-9608
dc.authoridBAYRAK, Hacer/0000-0001-5843-8716
dc.contributor.authorBayrak, Riza
dc.contributor.authorAkcay, Hakki Turker
dc.contributor.authorBeris, Fatih Saban
dc.contributor.authorSahin, Ertan
dc.contributor.authorBayrak, Hacer
dc.contributor.authorDemirbas, Umit
dc.date.accessioned2025-03-23T19:37:59Z
dc.date.available2025-03-23T19:37:59Z
dc.date.issued2014
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, novel phthalonitrile derivative (3) was synthesized by the reaction between 4-nitrophthalonitrile (2) and a triazole derivative (1) containing pyridine moiety. Crystal structure of compound (3) was characterized by X-ray diffraction. New metal free and metallo-phthalocyanine complexes (Zn, Cu, and Mg) were synthesized using the phthalonitrile derivative (3). Cationic derivatives of these phthalocyanines (5, 7, 9, and 11) were prepared from the non-ionic phthalocyanines (4, 6, 8, and 10). All proposed structures were supported by instrumental methods. The aggregation behaviors of the phthalocyanines (4-11) were investigated in different solvents such as dimethylsulfoxide (DMSO), N,N-dimethylformamide (DMF), chloroform and water. Water soluble cationic Pcs (5, 7, 9, and 11) aggregated in water and sodium dodecyl sulfate was used to prevent the aggregation. The second derivatives of the UV-Vis spectra of aggregated Pcs were used for analyzing the Q and B bands of aggregated species. Thermal behaviors of the phthalocyanines were also studied. In addition, anti-bacterial properties of the phthalocyanines were investigated. We used four gram negative and two gram positive bacteria to determine antibacterial activity of these compounds. Compound 7 has the best activity against the all bacteria with 125 mu g/mL of MIC value. Compounds 4, 6, and 10 have the similar effect on the bacteria with 250 mu g/mL of MIC value. (C) 2014 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.saa.2014.05.075
dc.identifier.endpage280
dc.identifier.issn1386-1425
dc.identifier.issn1873-3557
dc.identifier.pmid24952089
dc.identifier.scopus2-s2.0-84903214012
dc.identifier.scopusqualityQ1
dc.identifier.startpage272
dc.identifier.urihttps://doi.org/10.1016/j.saa.2014.05.075
dc.identifier.urihttps://hdl.handle.net/11486/6063
dc.identifier.volume133
dc.identifier.wosWOS:000340330900038
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofSpectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectCationic phthalocyanine
dc.subjectX-ray diffraction
dc.subjectAggregation
dc.subjectSodium dodecylsulfate
dc.subjectThermal stability
dc.subjectAnti-bacterial activity
dc.titleSynthesis, aggregation and spectroscopic studies of novel water soluble metal free, zinc, copper and magnesium phthalocyanines and investigation of their anti-bacterial properties
dc.typeArticle

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