Cord blood metabolomic profiling in high risk newborns born to diabetic, obese, and overweight mothers: preliminary report

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dc.contributor.authorUzun, Ozlem Unal
dc.contributor.authorEnes, Duygu
dc.contributor.authorCinar, Muge
dc.contributor.authorAdugit, Ayla Gunlemez
dc.contributor.authorUcar, Busra
dc.contributor.authorDuranoglu, Ali
dc.contributor.authorObuz, Ufuk Bozkurt
dc.date.accessioned2026-04-25T14:20:19Z
dc.date.available2026-04-25T14:20:19Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractObjectives Newborns of diabetic and obese/overweight mothers face long-term metabolic risks. Untargeted cord blood metabolomic analysis using quadrupole time-of-flight liquid chromatography/mass spectrometry (Q-TOF LC/MS) was performed to explore metabolic alterations and pathways in these high-risk infants.Methods Cord blood samples were collected from 46 newborns born to mothers with gestational diabetes (10), obesity (14), overweight (18), type 2 diabetes mellitus (3), type 1 diabetes mellitus (1), and 20 newborns born to healthy mothers. Q-TOF LC/MS was used to investigate the alterations in cord blood metabolomic profiles. Data processing was conducted using MZmine 2.53. Putative metabolites were idendtified using MetaboAnalyst 6.0.Results Distinct metabolite profiles were observed between diabetes and control groups. Significant identical trend in 19 metabolites were determined in both diabetes and obesity + overweight group vs. control group. Key pathways included steroid and bile acid biosynthesis. Upregulated oxidative stress, clues to sphingophospholipid metabolism, high levels of dihomo-gamma-linolenic acid (DGLA), pantothenic acid, and TRH were detected. The kynurenine pathway was prominent in the diabetes group.Conclusions Estrogen metabolites from the 16- and 2-pathways may indicate metabolic risk, with increased downstream flux under diabetic conditions. Accelerated bile acid synthesis may alter fetal metabolic programming, since bile acids play crucial roles in cellular energy regulation and signaling. Elevated pantothenic acid, essential for the production of coenzyme-A, suggests significant alterations in carbohydrate, protein, and fat metabolism. High serum DGLA levels emerge as a potential biomarker for metabolic abnormalities. Increased plasma kynurenines could predict cardiovascular risks. Larger targeted studies are required to validate these metabolic profiles and pathways.
dc.identifier.doi10.1515/jpem-2024-0605
dc.identifier.endpage589
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue6
dc.identifier.orcid0000-0003-4544-9285
dc.identifier.orcid0000-0003-4309-2331
dc.identifier.orcid0009-0007-0416-1185
dc.identifier.orcid0000-0001-7937-7721
dc.identifier.orcid0000-0002-1466-5746
dc.identifier.orcid0000-0001-7712-5512
dc.identifier.pmid40196912
dc.identifier.scopus2-s2.0-105002614147
dc.identifier.scopusqualityQ2
dc.identifier.startpage577
dc.identifier.urihttps://doi.org/10.1515/jpem-2024-0605
dc.identifier.urihttps://hdl.handle.net/11486/8512
dc.identifier.volume38
dc.identifier.wosWOS:001461232400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260420
dc.subjectmetabolomics
dc.subjectmaternal diabetes
dc.subjectmaternal obesity
dc.subjecthigh-risk newborn
dc.subjectquadrupole flight time mass spectrometer
dc.titleCord blood metabolomic profiling in high risk newborns born to diabetic, obese, and overweight mothers: preliminary report
dc.typeArticle

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