Synthesis, characterization, and investigations of antimicrobial activity of benzopyrans, benzofurans and spiro[4.5]decanes

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dc.authoridASLAN, Hakan/0000-0002-5268-7196
dc.contributor.authorAkpinar, Deniz E.
dc.contributor.authorOzgur (Nee Yakut), Mehtap
dc.contributor.authorAslan, Hakan
dc.contributor.authorAlagoz, Oguzhan
dc.contributor.authorOktemer, Atilla
dc.contributor.authorDal, Hakan
dc.contributor.authorHokelek, Tuncer
dc.date.accessioned2025-03-23T19:35:28Z
dc.date.available2025-03-23T19:35:28Z
dc.date.issued2018
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, the radical cyclization reactions of cyclic 1,3-dicarbonyl compounds (1a-c) and a, b-unsaturated alcohols (2a-d) through Mn(OAc) 3 were performed. A series of biologically interesting dihydropyrans (3-5) and dihydrofurans (6-18) were synthesized as a result of these reactions. Spiro compounds (19-20) were obtained from the reactions of 1,3-dicarbonyl compounds and (E)-2,4-diphenyl-but-3-en2-ol (2e). The unique structure of compound 19 was also confirmed by X-ray crystallography. In addition, the antibacterial activities of synthesized compounds were screened against some bacteria. Their zone diameters showed better results than some known antibiotics.
dc.description.sponsorshipAnkara University BAP [13B4240002]
dc.description.sponsorshipThis work was supported by a research grant from the Ankara University BAP [13B4240002].
dc.identifier.doi10.1080/00397911.2018.1509094
dc.identifier.endpage2521
dc.identifier.issn0039-7911
dc.identifier.issn1532-2432
dc.identifier.issue19
dc.identifier.scopus2-s2.0-85055130482
dc.identifier.scopusqualityQ2
dc.identifier.startpage2510
dc.identifier.urihttps://doi.org/10.1080/00397911.2018.1509094
dc.identifier.urihttps://hdl.handle.net/11486/5877
dc.identifier.volume48
dc.identifier.wosWOS:000452641300005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofSynthetic Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectBenzopyran
dc.subjectbenzofuran
dc.subjectspiro[4.5]decane
dc.subjectcyclization
dc.subjectmanganese(III) acetate
dc.titleSynthesis, characterization, and investigations of antimicrobial activity of benzopyrans, benzofurans and spiro[4.5]decanes
dc.typeArticle

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