Synthesis, characterization, and investigations of antimicrobial activity of benzopyrans, benzofurans and spiro[4.5]decanes
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, the radical cyclization reactions of cyclic 1,3-dicarbonyl compounds (1a-c) and a, b-unsaturated alcohols (2a-d) through Mn(OAc) 3 were performed. A series of biologically interesting dihydropyrans (3-5) and dihydrofurans (6-18) were synthesized as a result of these reactions. Spiro compounds (19-20) were obtained from the reactions of 1,3-dicarbonyl compounds and (E)-2,4-diphenyl-but-3-en2-ol (2e). The unique structure of compound 19 was also confirmed by X-ray crystallography. In addition, the antibacterial activities of synthesized compounds were screened against some bacteria. Their zone diameters showed better results than some known antibiotics.
Açıklama
Anahtar Kelimeler
Benzopyran, benzofuran, spiro[4.5]decane, cyclization, manganese(III) acetate
Kaynak
Synthetic Communications
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
48
Sayı
19
