Development of molecular imprinted nanosensor for determination of tobramycin in pharmaceuticals and foods

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dc.authoridUzun, Lokman/0000-0002-3971-7725
dc.contributor.authorYola, Mehmet Lutfi
dc.contributor.authorUzun, Lokman
dc.contributor.authorOzaltin, Nuran
dc.contributor.authorDenizli, Adil
dc.date.accessioned2025-03-23T19:37:46Z
dc.date.available2025-03-23T19:37:46Z
dc.date.issued2014
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, we developed quartz crystal microbalance (QCM) nanosensor for the real-time detection of tobramycin (TOB). Firstly, the modification of gold surface of QCM chip was performed by self-assembling monolayer formation of allyl mercaptane to introduce polymerizable double bonds on the chip surface. Then, TOB imprinted poly(2-hydroxyethyl methacrylate-methacryloylamidoglutamic acid) [p(HEMA-MAGA)] film was generated on the gold surface. The nonmodified and TOB-imprinted p(HEMA-MAGA) surfaces were characterized by using atomic force microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy, ellipsometry and contact angle measurements. The proposed method was validated according to the ICH guideline. The linearity range and the detection limit (S/N=3) were obtained as 1.7 x 10(-11)-1.5 x 10(-10) M and 5.7 x 10(-12) M, respectively. The developed method was applied to pharmaceuticals, and food samples such as chicken egg white and milk extract for the determination of TOB. In addition, association kinetics analysis and isotherm models were applied to the data to explain the adsorption process that took place. (C) 2013 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.talanta.2013.10.064
dc.identifier.endpage324
dc.identifier.issn0039-9140
dc.identifier.issn1873-3573
dc.identifier.pmid24468376
dc.identifier.scopus2-s2.0-84891672984
dc.identifier.scopusqualityQ1
dc.identifier.startpage318
dc.identifier.urihttps://doi.org/10.1016/j.talanta.2013.10.064
dc.identifier.urihttps://hdl.handle.net/11486/6007
dc.identifier.volume120
dc.identifier.wosWOS:000331917700043
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofTalanta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectTobramycin
dc.subjectQCM
dc.subjectMolecular imprinting
dc.subjectValidation
dc.subjectNanosensor
dc.titleDevelopment of molecular imprinted nanosensor for determination of tobramycin in pharmaceuticals and foods
dc.typeArticle

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