Evaluation of diffuse lymphadenopathy via various quantitative PET/CT parameters

Basit Öğe Kaydı
dc.contributor.authorSilov, Guler
dc.contributor.authorCankaya, Emel
dc.contributor.authorKaracavus, Seyhan
dc.date.accessioned2025-03-23T19:48:36Z
dc.date.available2025-03-23T19:48:36Z
dc.date.issued2023
dc.departmentSinop Üniversitesi
dc.description.abstractObjective: Discovery of diffuse lymphadenopathy (DLAP) in fluorine-18-fluorodeoxyglucose ( F-18-FDG) positron emission tomography/computed tomography (PET/CT) imaging alerts for the existence of many pathologic conditions with severity ranging from benign to malignancy. This study examines the role of various metabolic parameters reflecting F-18-FDG characteristics of organs/tissues to reach an accurate differential diagnosis for further clinical assessment. Materials and Methods: Positron emission tomography/CT images of 78 patients with DLAP were reviewed retrospectively. The diameter of the largest lymph node (DLlyn), maxi- mum standardized uptake value (SUVmax) of the liver (L), the largest lymph node (Llyn), spleen (S), and bone marrow (BM) were measured. Ratios to liver SUVmax were calculated for all, resulting LLRmax, SLRmax, and BMLRmax respectively. Results: The diameter of the largest lymph node, Llyn. SUVmax, LLRmax, and SLRmax produced cut-off values as 25.5, 8.86, 2.80, and 0.82 with corresponding sensitivity: specificity values as 65%:83%, 74%:77%, 74%:71%, and 79%:63% respectively for risk stratification of malignant causes. To differentiate lymphoma from sarcoidosis, DLlyn, SLRmax, and BMLRmax were found valuable with cut-off values obtained as 28.5, 0.84, and 1.19 with corresponding sensitivity: specificity values as 79%:91%, 79%:82%, and 54%:91%, respectively. Interdependency between parameters was also evaluated. Conclusion: High values of Llyn. Maximum SUV and LLRmax are the main characteristics of lymphoma, metastasis, and sarcoidosis. The diameter of the largest lymph node, SLRmax, and BMLRmax are determined as distinct parameters for distinguishing lymphoma from sarcoidosis. Besides, observed correlation structures amongst some PET/CT parameters were identified as nodal, extranodal, and diffuse patterns for three disease groups except sarcoidosis. These findings extend the knowledge about diagnostic factors based on F-18-FDG PET/CT patterns for DLAP.
dc.identifier.endpage56
dc.identifier.issn1108-1430
dc.identifier.issn1790-5427
dc.identifier.issue1
dc.identifier.pmid37031422
dc.identifier.scopus2-s2.0-85159244942
dc.identifier.scopusqualityQ3
dc.identifier.startpage47
dc.identifier.urihttps://hdl.handle.net/11486/7630
dc.identifier.volume26
dc.identifier.wosWOS:000988775600007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHellenic Soc Nuclear Medicine
dc.relation.ispartofHellenic Journal of Nuclear Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectF-18-FDGPET/CT
dc.subjectDiffuse lymphadenopathy
dc.subjectLymphoma
dc.subjectSarcoidosis
dc.subjectMetastasis
dc.subjectInfection/inammation
dc.titleEvaluation of diffuse lymphadenopathy via various quantitative PET/CT parameters
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu