The Effects of folic acid and topiramate on peripheral nerve regeneration

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dc.authoridsagir, dilek/0000-0002-6862-988X
dc.contributor.authorSagir, D.
dc.contributor.authorKuruoglu, E.
dc.contributor.authorOnger, M. E.
dc.contributor.authorYarar, E.
dc.date.accessioned2025-03-23T19:34:56Z
dc.date.available2025-03-23T19:34:56Z
dc.date.issued2020
dc.departmentSinop Üniversitesi
dc.description.abstractPeripheral nerve injury creates unusual sensitivity and pathological spontaneous activity in neurons that are described as ectopic discharge. Voltage dependent Na channels are responsible for ectopic discharge. Topiramate (TOP) inhibits voltage-gated sodium channels by blocking both the amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)/kainate receptor and folic acid (FA) activity in neurotransmitter synthesis reactions. FA and TOP are anti-apoptotic agents by both phosphorylated-Akt (p-Akt) signaling activation and anti-inflammatory effects at the injury site. We investigated the effects of FA and TOP in peripheral nerve injury. We used rats with a sciatic nerve injury (SNI) treated with FA or TOP once daily for 6 weeks. Histological and electrophysiological tests were used to evaluate the morphology, and motor and sensory functions. Numbers of axons, myelin sheath thickness and axon area were measured using stereological techniques; functionality also was evaluated. Although FA exhibited a positive effect on regeneration by increasing the number of axons, we found no difference in axonal outgrowth or myelin sheath formation between the TOP and FA groups.
dc.identifier.doi10.1080/10520295.2019.1637022
dc.identifier.endpage112
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2
dc.identifier.pmid31423848
dc.identifier.scopus2-s2.0-85070943199
dc.identifier.scopusqualityQ2
dc.identifier.startpage105
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1637022
dc.identifier.urihttps://hdl.handle.net/11486/5771
dc.identifier.volume95
dc.identifier.wosWOS:000482171100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectFolic acid
dc.subjectperipheral nerve
dc.subjectregeneration
dc.subjectstereology
dc.subjecttopiramate
dc.titleThe Effects of folic acid and topiramate on peripheral nerve regeneration
dc.typeArticle

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