A sensitive molecularly imprinted polymer based quartz crystal microbalance nanosensor for selective determination of lovastatin in red yeast rice

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dc.authoridKarimi-Maleh, Hassan/0000-0002-1027-481X
dc.authoridAtar, Necip/0000-0001-8779-1412
dc.contributor.authorEren, Tanju
dc.contributor.authorAtar, Necip
dc.contributor.authorYola, Mehmet Lutfi
dc.contributor.authorKarimi-Maleh, Hassan
dc.date.accessioned2025-03-23T19:41:41Z
dc.date.available2025-03-23T19:41:41Z
dc.date.issued2015
dc.departmentSinop Üniversitesi
dc.description.abstractLovastatin (LOV) is a statin, used to lower cholesterol which has been found as a hypolipidemic agent in commercial red yeast rice. In present study, a sensitive molecular imprinted quartz crystal microbalance (QCM) sensor was prepared by fabricating a self-assembling monolayer formation of allylmercaptane on QCM chip surface for selective determination of lovastatin (LOV) in red yeast rice. To prepare molecular imprinted quartz crystal microbalance (QCM) nanosensor, LOV imprinted poly(2-hydroxyethyl methacrylate-methacryloylamidoaspartic acid) [p(HEMA-MAAsp)] nanofilm was attached on the modified gold surface of QCM chip. The non-modified and improved surfaces were characterized by using contact angle, atomic force microscopy (AFM) and Fourier transform infrared (FTIR) spectroscopy. The imprinted QCM sensor was validated according to the ICH guideline (International Conference on Harmonisation). The linearity range was obtained as 0.10-1.25 nM. The detection limit of the prepared material was calculated as 0.030 nM. The developed QCM nanosensor was successfully used to examine red yeast rice. Furthermore, the stability and repeatability of the prepared QCM nanosensor were studied. The spectacular long-term stability and repeatability of the prepared LOV-imprinted QCM nanosensor make them intriguing for use in QCM sensors. (C) 2015 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipPamukkale University; Sinop University; Graduate University of Advanced Technology
dc.description.sponsorshipThe authors would like to thank Pamukkale University, Sinop University and Graduate University of Advanced Technology for support.
dc.identifier.doi10.1016/j.foodchem.2015.03.153
dc.identifier.endpage436
dc.identifier.issn0308-8146
dc.identifier.issn1873-7072
dc.identifier.pmid25952889
dc.identifier.scopus2-s2.0-84927740690
dc.identifier.scopusqualityQ1
dc.identifier.startpage430
dc.identifier.urihttps://doi.org/10.1016/j.foodchem.2015.03.153
dc.identifier.urihttps://hdl.handle.net/11486/6613
dc.identifier.volume185
dc.identifier.wosWOS:000355027100056
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofFood Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectMolecularly imprinting
dc.subjectLovastatin
dc.subjectQCM
dc.subjectNanosensor
dc.subjectValidation
dc.titleA sensitive molecularly imprinted polymer based quartz crystal microbalance nanosensor for selective determination of lovastatin in red yeast rice
dc.typeArticle

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