Adding New Scientific Evidences on the Pharmaceutical Properties of Pelargonium quercetorum Agnew Extracts by Using In Vitro and In Silico Approaches

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dc.authoridDi Simone, Simonetta Cristina/0000-0001-5041-3848
dc.authoridZengin, Gokhan/0000-0001-6548-7823
dc.authorid, Claudio/0000-0001-9431-9407
dc.authorid, Nilofar/0000-0002-4254-4140
dc.authoridElkiran, Omer/0000-0003-1933-4003
dc.authoridCakilcioglu, Prof. Dr. Ugur/0000-0002-3627-3604
dc.authoridLibero, Maria Loreta/0000-0002-8133-5691
dc.contributor.authorChiavaroli, Annalisa
dc.contributor.authorLibero, Maria Loreta
dc.contributor.authorDi Simone, Simonetta Cristina
dc.contributor.authorAcquaviva, Alessandra
dc.contributor.authorNilofar
dc.contributor.authorRecinella, Lucia
dc.contributor.authorLeone, Sheila
dc.date.accessioned2025-03-23T19:26:18Z
dc.date.available2025-03-23T19:26:18Z
dc.date.issued2023
dc.departmentSinop Üniversitesi
dc.description.abstractPelargonium quercetorum is a medicinal plant traditionally used for treating intestinal worms. In the present study, the chemical composition and bio-pharmacological properties of P. quercetorum extracts were investigated. Enzyme inhibition and scavenging/reducing properties of water, methanol, and ethyl acetate extracts were assayed. The extracts were also studied in an ex vivo experimental model of colon inflammation, and in this context the gene expression of cyclooxygenase-2 (COX-2) and tumor necrosis factor alpha (TNF alpha) were assayed. Additionally, in colon cancer HCT116 cells, the gene expression of transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), possibly involved in colon carcinogenesis, was conducted as well. The extracts showed a different qualitative and quantitative content of phytochemicals, with water and methanol extracts being richer in total phenols and flavonoids, among which are flavonol glycosides and hydroxycinnamic acids. This could explain, at least in part, the higher antioxidant effects shown by methanol and water extracts, compared with ethyl acetate extract. By contrast, the ethyl acetate was more effective as cytotoxic agent against colon cancer cells, and this could be related, albeit partially, to the content of thymol and to its putative ability to downregulate TRPM8 gene expression. Additionally, the ethyl acetate extract was effective in inhibiting the gene expression of COX-2 and TNF alpha in isolated colon tissue exposed to LPS. Overall, the present results support future studies for investigating protective effects against gut inflammatory diseases.
dc.description.sponsorshipMIUR [2017XC73BW]
dc.description.sponsorshipThis work was supported by the National Grant Progetti di Rilevante Interesse Nazionale (PRIN) 2017 [project number 2017XC73BW] from MIUR.
dc.identifier.doi10.3390/plants12051132
dc.identifier.issn2223-7747
dc.identifier.issue5
dc.identifier.pmid36903991
dc.identifier.scopus2-s2.0-85149955818
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.3390/plants12051132
dc.identifier.urihttps://hdl.handle.net/11486/4680
dc.identifier.volume12
dc.identifier.wosWOS:000948073800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofPlants-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectPelargonium quercetorum
dc.subjectphenolic compounds
dc.subjectantioxidant
dc.subjectenzyme inhibition
dc.subjectcolon inflammation
dc.subjectTRPM8
dc.subjectCOX-2
dc.subjectTNF alpha
dc.titleAdding New Scientific Evidences on the Pharmaceutical Properties of Pelargonium quercetorum Agnew Extracts by Using In Vitro and In Silico Approaches
dc.typeArticle

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