Activation of 6-bromoquinoline by nitration: synthesis of morpholinyl and piperazinyl quinolines

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dc.authoridAlimli, Dilek/0000-0003-4564-9447
dc.authoridOkten, Salih/0000-0001-9656-1803
dc.contributor.authorCakmak, Osman
dc.contributor.authorOkten, Salih
dc.contributor.authorAlimli, Dilek
dc.contributor.authorSaddiqa, Aisha
dc.contributor.authorErsanli, Cem Cuneyt
dc.date.accessioned2025-03-23T19:26:59Z
dc.date.available2025-03-23T19:26:59Z
dc.date.issued2018
dc.departmentSinop Üniversitesi
dc.description.abstractQuinoline forms the key skeletal component of a number of important natural products and pharmacologically-active compounds. Despite a tremendous amount of research pertaining to the derivatization of quinoline, very few general synthetic routes are described in the literature starting from quinoline or tetrahydroquinoline. A simple and convenient method for the polyfunctionalization of quinolines via nitration of bromoquinolines has been developed. This method represents a new synthetic approach to convert brominated nitroquinoline derivatives into useful cyclic amines via nucleophilic-substitution (SNAr) reaction. [GRAPHICS] .
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [112T394]
dc.description.sponsorshipThis study was financially supported by grants from the Scientific and Technological Research Council of Turkey (TUBITAK, Project number: 112T394). The authors thank the Scientific and Technological Research Application and Research Center, Sinop University, Turkey, for the use of the Bruker D8-QUEST diffractometer.
dc.identifier.doi10.24820/ark.5550190.p010.374
dc.identifier.endpage374
dc.identifier.issn1551-7004
dc.identifier.issn1551-7012
dc.identifier.scopus2-s2.0-85049176940
dc.identifier.scopusqualityQ4
dc.identifier.startpage362
dc.identifier.urihttps://doi.org/10.24820/ark.5550190.p010.374
dc.identifier.urihttps://hdl.handle.net/11486/4804
dc.identifier.wosWOS:000438799100030
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherArkat Usa Inc
dc.relation.ispartofArkivoc
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectNitration
dc.subjectN-oxidation
dc.subject6-bromoquinoline
dc.subjectaminoquinoline
dc.subjectquinoline N-oxides
dc.subjectmorpholinyl and piperazinyl quinolines
dc.titleActivation of 6-bromoquinoline by nitration: synthesis of morpholinyl and piperazinyl quinolines
dc.typeArticle

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