Activation of 6-bromoquinoline by nitration: synthesis of morpholinyl and piperazinyl quinolines
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Arkat Usa Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Quinoline forms the key skeletal component of a number of important natural products and pharmacologically-active compounds. Despite a tremendous amount of research pertaining to the derivatization of quinoline, very few general synthetic routes are described in the literature starting from quinoline or tetrahydroquinoline. A simple and convenient method for the polyfunctionalization of quinolines via nitration of bromoquinolines has been developed. This method represents a new synthetic approach to convert brominated nitroquinoline derivatives into useful cyclic amines via nucleophilic-substitution (SNAr) reaction. [GRAPHICS] .
Açıklama
Anahtar Kelimeler
Nitration, N-oxidation, 6-bromoquinoline, aminoquinoline, quinoline N-oxides, morpholinyl and piperazinyl quinolines
Kaynak
Arkivoc
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
