Dose-dependent effects of prenatal exposure of pioglitazone, the PPARγ agonist, on the hippocampus development and learning and memory performance of rat offspring

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dc.contributor.authorSagir, Dilek
dc.date.accessioned2025-03-23T19:37:46Z
dc.date.available2025-03-23T19:37:46Z
dc.date.issued2021
dc.departmentSinop Üniversitesi
dc.description.abstractIt is known that pioglitazone, defined as a PPAR gamma agonist, has neuron-protective properties in nervous system disorders. The aim of this study is to investigate the effects of pioglitazone administration at different doses during prenatal period on the neurons, glial cells and learning-memory levels in the hippocampus of rat offspring. Pregnant rats were divided into three groups; Low-Dose Pioglitazone (LDP), High-Dose Pioglitazone (HDP) and control (C) (n = 3). Pregnant rats in the HDP and LDP groups were given pioglitazone at 30 mg/kg and 5 mg/ kg doses, respectively, by gavage once a day during their pregnancy. No procedure was applied to the rats in the control group. Morris water tank test was applied to offspring obtained from postnatal 24th to 28th day. The offspring were sacrificed on the 29th postal day and their brain tissues removed. Stereological, histopathological and immunohistochemical techniques were used to analyze brain tissues. As a result of the analysis, it was observed that there were delays in learning and memory, the number of pyramidal neurons decreased, and the density of cells stained with glial fibrillar acidic protein (GFAP) positive increased in the HDP group compared to the other groups (p < 0.05). No significant difference was found between the LDP and control groups in terms of these parameters (p > 0.05). Our results showed that pioglitazone administered in the prenatal period had an effect on the hippocampus development and learning and memory performance of rats, depending on the dose.
dc.identifier.doi10.1016/j.taap.2021.115544
dc.identifier.issn0041-008X
dc.identifier.issn1096-0333
dc.identifier.pmid33894214
dc.identifier.scopus2-s2.0-85105834389
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.taap.2021.115544
dc.identifier.urihttps://hdl.handle.net/11486/6008
dc.identifier.volume421
dc.identifier.wosWOS:000652660100005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSagir, Dilek
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofToxicology and Applied Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectPioglitazone
dc.subjectPPAR gamma
dc.subjectHippocampus
dc.subjectNeurotoxicity
dc.subjectGlial fibrillar acidic protein (GFAP)
dc.subjectLearning and memory
dc.titleDose-dependent effects of prenatal exposure of pioglitazone, the PPARγ agonist, on the hippocampus development and learning and memory performance of rat offspring
dc.typeArticle

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