Biological, computational evaluation of novel benzofuranyl derivatives as acetylcholinesterase and butyrylcholinesterase

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dc.authoridUba, Abdullahi Ibrahim/0000-0002-0853-108X
dc.contributor.authorUsanmaz, Hande
dc.contributor.authorTas, Omer
dc.contributor.authorEkinci, Deniz
dc.contributor.authorUba, Abdullahi Ibrahim
dc.contributor.authorAtmaca, Ufuk
dc.date.accessioned2025-03-23T19:34:41Z
dc.date.available2025-03-23T19:34:41Z
dc.date.issued2024
dc.departmentSinop Üniversitesi
dc.description.abstractAim: A highly efficient one-step method has been developed for the synthesis of benzofuranyl derivatives from 2-benzoylcyclohexane-1-carboxylic acid derivatives using chlorosulfonyl isocyanate. This novel method provides a practical, cost-effective and efficient approach. Materials & methods: The inhibitory effects of benzofuranyl derivatives on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were investigated. Ki values were determined to range from 0.009 to 0.61 mu M for AChE and 0.28 to 1.60 mu M for BChE. Molecular docking analysis provided insights into the interaction modes and binding patterns of these compounds with AChE and BChE. Conclusion: Kinetic findings of our study suggest that some of our compounds exhibited more effective low micromolar inhibition compared with the reference, and these derivatives could be to design more powerful agents.
dc.identifier.doi10.1080/17568919.2024.2342641
dc.identifier.endpage1085
dc.identifier.issn1756-8919
dc.identifier.issn1756-8927
dc.identifier.issue11
dc.identifier.pmid38916565
dc.identifier.scopus2-s2.0-85194750186
dc.identifier.scopusqualityQ2
dc.identifier.startpage1075
dc.identifier.urihttps://doi.org/10.1080/17568919.2024.2342641
dc.identifier.urihttps://hdl.handle.net/11486/5709
dc.identifier.volume16
dc.identifier.wosWOS:001236934400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofFuture Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectacetylcholinesterase
dc.subjectAlzheimer's disease
dc.subjectbenzofuranyl
dc.subjectbutyrylcholinesterase
dc.subjectmolecular modeling
dc.titleBiological, computational evaluation of novel benzofuranyl derivatives as acetylcholinesterase and butyrylcholinesterase
dc.typeArticle

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