Carbon nanofiber-enhanced molecular imprinted electrochemical sensor for hypoxanthine detection

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dc.contributor.authorArmutcu, Canan
dc.contributor.authorPiskin, Sena
dc.contributor.authorOzgur, Erdogan
dc.contributor.authorKarakaya, Mustafa
dc.contributor.authorCorman, M. Emin
dc.contributor.authorUzun, Lokman
dc.date.accessioned2026-04-25T14:19:47Z
dc.date.available2026-04-25T14:19:47Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractA molecularly imprinted electrochemical sensor (MIP) was developed using thymine-functionalized carbon nanofibers (Thy@CNFs) to enable selective detection of hypoxanthine (HYP). The sensor was fabricated by first depositing Thy@CNFs onto a glassy carbon electrode (GCE), followed by electropolymerization of a pyrrole-co-pyrrole-3-carboxylic acid (Py-co-PyCOOH) copolymer in the presence of HYP. Each modification step was characterized using electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), and contact angle measurements. Under optimized conditions, the Thy@CNFs-modified MIP sensor (Thy@CNFs/MIP/GCE) exhibited a linear response to HYP concentrations ranging from 1 x 10-9 to 1 x 10-8 M, with a detection limit of 1.71 x 10-10 M. Finally, the sensor was successfully applied to commercial serum and artificial urine sample, achieving recoveries of 99.55% and 100.17%, respectively, demonstrating its accuracy, precision, and practical applicability in real sample analysis.
dc.identifier.doi10.1007/s00604-025-07502-5
dc.identifier.issn0026-3672
dc.identifier.issn1436-5073
dc.identifier.issue10
dc.identifier.pmid40938432
dc.identifier.scopus2-s2.0-105015644260
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00604-025-07502-5
dc.identifier.urihttps://hdl.handle.net/11486/8186
dc.identifier.volume192
dc.identifier.wosWOS:001571593200002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofMicrochimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260420
dc.subjectHypoxanthine
dc.subjectCNFs
dc.subjectThymine
dc.subjectMolecular imprinting
dc.subjectModified glassy carbon electrode
dc.subjectDifferential pulse voltammetry
dc.titleCarbon nanofiber-enhanced molecular imprinted electrochemical sensor for hypoxanthine detection
dc.typeArticle

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