Microplastic-induced oxidative stress response in turbot and potential intake by humans

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dc.authoridDUYAR, Hunkar Avni/0000-0002-2560-5407
dc.authoridparlak, veysel/0000-0002-3459-7963
dc.authoridATAMANALP, MUHAMMED/0000-0002-2038-3921
dc.contributor.authorKokturk, Mine
dc.contributor.authorOzgeris, Fatma Betuel
dc.contributor.authorAtamanalp, Muhammed
dc.contributor.authorUcar, Arzu
dc.contributor.authorOzdemir, Suleyman
dc.contributor.authorParlak, Veysel
dc.contributor.authorDuyar, Hunkar Avni
dc.date.accessioned2025-03-23T19:35:21Z
dc.date.available2025-03-23T19:35:21Z
dc.date.issued2024
dc.departmentSinop Üniversitesi
dc.description.abstractMicroplastic (MP) pollution has become a health concern subject in recent years. Althoughann increasing number of studies about the ingestion of microplastics by fish, research on the oxidative stress response to MPs in natural environments is quite limited. In this study, the identification and characterization of MPs in gill (G), muscle tissues (M), and gastrointestinal tract (GI) of turbot (Scophthalmus maximus) were evaluated. Oxidative damage of MPs on the brain (B), liver (L), gill (G), and muscle (M) tissues as well as their effect on superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), paraoxonase (PON), arylesterase (AR) myeloperoxidase (MPO), and malondialdehyde (MDA) biomarkers were evaluated. The potential transmission of MPs from muscle tissues to humans was examined. Results showed that gills contain the highest amounts of MPs, ethylene propylene is the most dominant polymer type, black and blue are the most common MP color, fiber is the most common shape, and 50-200 mu m is the most common MP size. Results showed that MPs cause oxidative stress of tissues with inhibiting effect on enzyme activities and promoting impact on lipid peroxidation. The oxidative damage mostly affected the liver (detoxification organ) followed by gill tissue. The intake of MPS in the European Union was estimated by EFSA as 119 items/year, while in Turkey it is 47.88 items/year. This study shows that more research is needed in terms of ecosystem health and food chain safety. The risk assessment of MPs in living organisms and environmental matrices including food safety and human health should be considered a public health issue.
dc.identifier.doi10.1080/01480545.2023.2168690
dc.identifier.endpage305
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue3
dc.identifier.pmid36656072
dc.identifier.scopus2-s2.0-85147030753
dc.identifier.scopusqualityQ1
dc.identifier.startpage296
dc.identifier.urihttps://doi.org/10.1080/01480545.2023.2168690
dc.identifier.urihttps://hdl.handle.net/11486/5850
dc.identifier.volume47
dc.identifier.wosWOS:000913700600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofDrug and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectDemersal fish
dc.subjectmicroplastics
dc.subjectoxidative damage
dc.subjectbiochemical changes
dc.subjectToxicity
dc.subjecthuman health
dc.titleMicroplastic-induced oxidative stress response in turbot and potential intake by humans
dc.typeArticle

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