The Evaluation of Serum Endocan, Interleukin-6, and CRP Levels Following Sleeve Gastrectomy

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dc.authoridDURSUN, ALI DOGAN/0000-0001-9056-0025
dc.contributor.authorSariyildiz, Gulcin Turkmen
dc.contributor.authorDemir, Canan Cicek
dc.contributor.authorDemir, Mehmet Emin
dc.contributor.authorArslan, Aykut Ilker
dc.contributor.authorBanli, Oktay
dc.contributor.authorDursun, Ali Dogan
dc.date.accessioned2025-03-23T19:27:17Z
dc.date.available2025-03-23T19:27:17Z
dc.date.issued2023
dc.departmentSinop Üniversitesi
dc.description.abstractBackground: The excessive accumulation of fat tissue in obesity is the source of chronic low-level inflammation and causes future dysmetabolic and cardiovascular disorders. Removal of this excessive fat tissue with the aid of bariatric surgery (BS) techniques, such as sleeve gastrectomy, may reverse adverse inflammatory outcomes. The aim of this study is to investigate the impact of sleeve gastrectomy on inflammatory markers, specifically endocan, IL-6, and CRP, in individuals with obesity.Methods: Thirty-two patients with class 3 obesity and class 2 obesity + comorbidities were enrolled in the study. Clinical characteristics including age, comorbidity, body mass index (BMI), waist, and hip circumferences of the participants were noted before and 3 months after sleeve gastrectomy. Blood samples were collected during those periods to assess biochemical features such as serum endocan, interleukin-6 (IL-6), C-reactive peptide, fasting insulin, glycosylated hemoglobin A1c levels, and lipid panel. A statistical package program was used for the analysis of those parameters, and p<0.05 was accepted as significant at a 95.0% confidence interval.Results: BMI reduced from 43.55 +/- 6.78 to 36.16 +/- 6.14 kg/m(2) within 3 months following BS (p<0.001). Preoperative serum endocan, IL-6, and CRP levels were correlated with BMI, and in line with BMI reduction, their serum levels decreased after BS (p<0.05). HOMA-IR also reduced after BS, and both in the pre and post-BS periods correlated with BMI, IL-6, endocan, and CRP levels (p<0.05). The mean total body weight loss was 20.4% within 3 months post-BS.Conclusion: BS techniques are effective in weight loss and reversing the inflammatory processes caused by obesity. Serum endocan, IL-6, and CRP levels are promising markers for describing obesity-related inflammation and objectively checking the alleviation of inflammation following BS.
dc.identifier.doi10.2147/IJGM.S436213
dc.identifier.endpage4744
dc.identifier.issn1178-7074
dc.identifier.pmid37877002
dc.identifier.scopusqualityN/A
dc.identifier.startpage4737
dc.identifier.urihttps://doi.org/10.2147/IJGM.S436213
dc.identifier.urihttps://hdl.handle.net/11486/4883
dc.identifier.volume16
dc.identifier.wosWOS:001090689700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofInternational Journal of General Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectbariatric surgery
dc.subjectendocan
dc.subjectinterleukin-6
dc.subjectsleeve gastrectomy
dc.subjectweight loss
dc.titleThe Evaluation of Serum Endocan, Interleukin-6, and CRP Levels Following Sleeve Gastrectomy
dc.typeArticle

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