Effect of sildenafil on intestinal adaptation parameters in a rat model of short bowel syndrome

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dc.contributor.authorBilecik, T.
dc.contributor.authorEnsari, C.
dc.contributor.authorMayir, B.
dc.contributor.authorCakir, T.
dc.contributor.authorMinareci, E.
dc.contributor.authorArslan, U.
dc.contributor.authorOruc, T.
dc.date.accessioned2025-03-23T19:48:38Z
dc.date.available2025-03-23T19:48:38Z
dc.date.issued2016
dc.departmentSinop Üniversitesi
dc.description.abstractOBJECTIVE: We aimed to evaluate the effect of sildenafil on the intestinal adaptation in short bowel syndrome (SBS). MATERIALS AND METHODS: Forty-eight male Wistar-albino rats (weight, 231-390 g) were randomly divided into four groups with 12 rats in each. Group TA had only ileal transection+anastomosis, Group TA+S was given sildenafil after ileal transection+anastomosis, Group RA had a resection of 75% of the small bowel+anastomosis, Group RA+S was given sildenafil after small bowel resection+anastomosis. Sildenafil was injected subcutaneously at 60 mg/kg/day dose throughout 3-21 days postoperatively. Bowel and mucosal weights, villus height, crypt depth, DNA and protein concentrations were determined. RESULTS: Jejunal bowel weight was lower in TA and TA+S groups than RA and RA+S groups (p < 0.05). RA+S group had higher ileal and jejunal mucosal weights than RA and TA+S groups (p < 0.05). Villus height was highest in RA+S group both in ileum and jejunum (466.1 +/- 38.6 mu m and 648.1 +/- 65.7 mu m, respectively). Jejunal crypt depth was highest in RA+S group (255.1 +/- 21.9 mu m) compared to other groups (p < 0.05). There was no significant difference in ileal and jejunal protein concentration between TA and TA+S groups and in ileal protein concentration between RA ve RA+S groups (p > 0.05). Ileal DNA concentration was higher in TA+S group, and jejunal DNA concentration was higher in RA and RA+S groups than TA and TA+S groups (p < 0.05). CONCLUSIONS: Sildenafil has a positive effect on intestinal adaptation parameters, particularly in jejunum in a rat SBS model. Thus, its role in the treatment of SBS should be further investigated with clinical studies.
dc.identifier.endpage527
dc.identifier.issn1128-3602
dc.identifier.issue3
dc.identifier.pmid26914129
dc.identifier.scopusqualityQ2
dc.identifier.startpage520
dc.identifier.urihttps://hdl.handle.net/11486/7642
dc.identifier.volume20
dc.identifier.wosWOS:000371386300021
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectShort bowel syndrome
dc.subjectIntestinal adaptation
dc.subjectSildenafil
dc.titleEffect of sildenafil on intestinal adaptation parameters in a rat model of short bowel syndrome
dc.typeArticle

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