Copper(II) and zinc(II) complexes of N2O2-thiosemicarbazones as inhibitors of Mycobacterium tuberculosis and bacterial quorum sensing

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dc.contributor.authorKaya, Busra
dc.contributor.authorVagolu, Siva Krishna
dc.contributor.authorKaraguzel, Ayse
dc.contributor.authorBogojevic, Sanja Skaro
dc.contributor.authorSahin, Onur
dc.contributor.authorTonjum, Tone
dc.contributor.authorNikodinovic-Runic, Jasmina
dc.date.accessioned2026-04-25T14:19:59Z
dc.date.available2026-04-25T14:19:59Z
dc.date.issued2026
dc.departmentSinop Üniversitesi
dc.description.abstractThe rise of resistance to existing antimicrobial drugs has become a significant global health concern, underscoring the urgent need for new and effective antimicrobial agents. In this context, we prepared six copper(II) (Cu1-Cu6) and six zinc(II) (Zn1-Zn6) complexes bearing N2O2-thiosemicarbazones and confirmed their structures by spectral techniques, including X-ray diffraction analysis. The antimicrobial potential of the target compounds was initially tested against drug-sensitive and isoniazid-resistant Mycobacterium tuberculosis strains. Cu(II)-based complexes were identified as more effective antitubercular agents with negligible cytotoxicity compared to Zn(II)-including counterparts. Furthermore, Cu1-Cu6 and Zn1-Zn6 were tested for their antibacterial and antifungal properties. Although the compounds failed to inhibit the growth of bacterial and fungal strains at low concentrations, Zn1 and Zn2 were determined as effective blockers of the bacterial cell-to-cell communication system known as quorum sensing. Finally, molecular docking studies indicated that inhibiting the enoyl acyl carrier protein reductase (InhA) enzyme could be the mechanism behind the significant antitubercular activity of Cu2. Overall, our study shows that copper(II) and zinc(II) complexes of thiosemicarbazones are promising agents against bacterial infections due to their antitubercular and anti-quorum sensing activities.
dc.description.sponsorshipScientific and Technological Research Application and Research Center, Sinop University, Turkey; Scientific and Technological Research Council of Turkiye (TUBITAK) through the 2211-A National PhD Scholarship Program
dc.description.sponsorshipThe authors acknowledge to Scientific and Technological Research Application and Research Center, Sinop University, Turkey, for the use of the Bruker D8 QUEST diffractometer. MGG would like to thank Prof. Dr. Gerhard Wolber, Freie Universitat Berlin, for providing the license for LigandScout 4.5. AK gratefully acknowledges the financial support provided by The Scientific and Technological Research Council of Turkiye (TUBITAK) through the 2211-A National PhD Scholarship Program.
dc.identifier.doi10.1016/j.molstruc.2026.145676
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-105034215090
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2026.145676
dc.identifier.urihttps://hdl.handle.net/11486/8300
dc.identifier.volume1362
dc.identifier.wosWOS:001701209400009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260420
dc.subjectAntibacterial
dc.subjectAntitubercular
dc.subjectAntimicrobial
dc.subjectTuberculosis
dc.subjectThiosemicarbazone
dc.subjectCytotoxicity
dc.titleCopper(II) and zinc(II) complexes of N2O2-thiosemicarbazones as inhibitors of Mycobacterium tuberculosis and bacterial quorum sensing
dc.typeArticle

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