Synthesis, Characterization, Biological Activity and Molecular Modeling Studies of Novel Aminoguanidine Derivatives

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dc.authoridKilic, Turker/0009-0008-4748-4563
dc.authoridSahin, Kader/0000-0002-9056-9000
dc.authoridTAPERA, MICHAEL/0000-0001-9584-1731
dc.contributor.authorDogan, Nuriye
dc.contributor.authorYavuz, Sevtap Caglar
dc.contributor.authorSahin, Kader
dc.contributor.authorOrhan, Muge Didem
dc.contributor.authorMuhammed, Huseyin Kekec
dc.contributor.authorCalis, Seyma
dc.contributor.authorKup, Fatma Ozturk
dc.date.accessioned2025-03-23T19:47:06Z
dc.date.available2025-03-23T19:47:06Z
dc.date.issued2022
dc.departmentSinop Üniversitesi
dc.description.abstractIn recent years, various compounds including the aminoguanidine scaffold have been reported to exhibit diverse biological activities. In the current study, 16 compounds that include guanylhydrazone (aminoguanidine) moiety (3 a-3 p) were synthesized and characterized through the spectrum data, including H-1-NMR, C-13-NMR, and FT-IR. Furthermore, the proposed structure of 3 a was resolved by single-crystal X-ray diffractometer. The prepared compounds were then tested for their different in vitro biological activities including antitumor activities against several types of cancer cell lines (A549, MCF-7, and U87-MG). Results showed that among the studied compounds especially 3 i, 3 n, and 3 p showed promising antiproliferative effect and they may be considered as good candidates for further in vitro and/or in vivo animal model studies. All the 16 derivatives synthesized in this study were also screened for their antimicrobial, antioxidant activity and DNA cleavage properties. Furthermore, multidimensional molecular modeling approaches were conducted for better understanding of their biological activities in atomic level.
dc.description.sponsorshipResearch Foundation of Erciyes University [FOA-2014-5365, FYL-2016-6424]
dc.description.sponsorshipThe authors are indebted to the Research Foundation of Erciyes University (Grant No:FOA-2014-5365 and FYL-2016-6424). SA would like to thank Erciyes University Genome and Stem Cell Center (GENKOK) for allowing her to carry out cytotoxic activity studies in its laboratories.
dc.identifier.doi10.1002/slct.202202819
dc.identifier.issn2365-6549
dc.identifier.issue45
dc.identifier.scopus2-s2.0-85143701326
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202202819
dc.identifier.urihttps://hdl.handle.net/11486/7280
dc.identifier.volume7
dc.identifier.wosWOS:000895013300075
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectaminoguanidine
dc.subjectBCL-2
dc.subjectDNA cleavage
dc.subjectguanylhydrazone
dc.subjectmolecular modeling
dc.titleSynthesis, Characterization, Biological Activity and Molecular Modeling Studies of Novel Aminoguanidine Derivatives
dc.typeArticle

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