Oxidative stress-induced apoptotic changes after acute exposure to antifouling agent zinc pyrithione (ZnPT) in Mytilus galloprovincialis Lamark (Mediterranean mussels) tissues

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dc.authoridYavasoglu, Altug/0000-0003-4227-1637
dc.authoridGUNAL, AYSEL CAGLAN/0000-0002-9072-543X
dc.authoridKarabay Yavasoglu, N.Ulku/0000-0002-7483-0184
dc.authoridGUNER, ADEM/0000-0003-3295-3538
dc.authoridYigitturk, Gurkan/0000-0002-5315-253X
dc.authoridDagdeviren, Melih/0000-0001-8048-3302
dc.contributor.authorKatalay, Selma
dc.contributor.authorGuner, Adem
dc.contributor.authorDagdeviren, Melih
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorYavasoglu, Altug
dc.contributor.authorGunal, A. Caglan
dc.contributor.authorYavasoglu, N. Ulku Karabay
dc.date.accessioned2025-03-23T19:35:17Z
dc.date.available2025-03-23T19:35:17Z
dc.date.issued2022
dc.departmentSinop Üniversitesi
dc.description.abstractZinc pyrithione (ZnPT) is one of the components used in antifouling paints and can be an alternative to classical toxic chemicals such as organotin. However, there is still remarkable concern about the environmental safeness of ZnPT due to rapid transchelation and degradation into several metabolites that have their own toxicity. The effect after acute exposure of ZnPT is investigated on Mediterranean mussels exposed to 20 and 40 mu g/L concentrations for 48 and 96 h and antioxidant responses [superoxide dismutase (SOD), and reduced glutathione (GSH)], genotoxicity [micronuclei (MN) frequency], apoptotic and histological changes were determined. Severe histological changes in hepatopancreas and gill tissues of mussels were observed in ZnPT exposed groups due to dose-dependent increase. ZnPT also caused a dose-dependent increase of TUNEL-positive cell count in the mussel tissues, especially in the hepatopancreas. Increasing in SOD activities and decreasing in GSH levels in both ZnPT concentrations compared to the control were observed. MN and binuclei numbers in all exposure groups were significantly increased. The results of the present study demonstrate that acute exposure to ZnPT could cause an adverse effect on mussel tissues at especially higher concentrations.
dc.description.sponsorshipManisa Celal Bayar University BAP project [2014-154]
dc.description.sponsorshipThe study is supported by Manisa Celal Bayar University BAP project (2014-154).
dc.identifier.doi10.1080/02757540.2022.2047951
dc.identifier.endpage373
dc.identifier.issn0275-7540
dc.identifier.issn1029-0370
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85126475322
dc.identifier.scopusqualityQ2
dc.identifier.startpage356
dc.identifier.urihttps://doi.org/10.1080/02757540.2022.2047951
dc.identifier.urihttps://hdl.handle.net/11486/5835
dc.identifier.volume38
dc.identifier.wosWOS:000767671700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofChemistry and Ecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectMussel
dc.subjectzinc pyrithione
dc.subjectapoptosis
dc.subjecthistology
dc.subjectbiochemical effects
dc.subjectmicronuclei
dc.titleOxidative stress-induced apoptotic changes after acute exposure to antifouling agent zinc pyrithione (ZnPT) in Mytilus galloprovincialis Lamark (Mediterranean mussels) tissues
dc.typeArticle

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