Green and Facile Reaction of Gabapentin with Sulfonyl Chlorides to Synthesize Lactams and Sulfonamides Derivatives in Aqueous Medium

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dc.authoridMutahir, Sadaf/0000-0002-4126-602X
dc.authoridAkkurt, Mehmet/0000-0003-2421-0929
dc.authoridKhan, Dr. Muhammad Asim/0000-0002-7683-0102
dc.contributor.authorHussain, Erum Akbar
dc.contributor.authorKanwal, Nosheen
dc.contributor.authorKhan, Islam Ullah
dc.contributor.authorMutahir, Sadaf
dc.contributor.authorKhan, Muhammad Asim
dc.contributor.authorAhmed, Maqsood
dc.contributor.authorMahmood, Arshad
dc.date.accessioned2025-03-23T19:27:13Z
dc.date.available2025-03-23T19:27:13Z
dc.date.issued2018
dc.departmentSinop Üniversitesi
dc.description.abstractIn the current research, a facile and green one pot synthesis of new gabapentin-lactams (G(2)-G(8)) has been achieved by reacting gabapentin (G(1)) with a variety of sulfonyl chlorides. The new lactamization protocol is furnished under the green solvent i.e., water and reaction was completed in a short period of time by just stirring at room temperature. Whereas in some cases, annulation could not happen and furnished un-cyclized sulfonamide products (G(9)-G(12)). The structures of the targeted compounds were established by elemental analysis, FT-IR, H-1-NMR and mass spectrometry. The crystals of some new lactams (G(2), G(3), G(4), and G(8)) were also evaluated by single crystal X-ray diffraction.
dc.description.sponsorshipHigher Education Commission
dc.description.sponsorshipWe acknowledge Higher Education Commission for financial support. Authors would like to thank Prof. Khalid M. Khan, HEJ Institute of Chemistry, University of Karachi, Dr. Saif Ullah Salik, University of Oxford, UK for their kind assistance in 1H NMR and mass spectral measurements and Dr. Shahzad Sharif, Department of Chemistry, GCU, Lahore for his kind assistance in X-ray diffraction studies.
dc.identifier.doi10.2174/1570178614666170907143340
dc.identifier.endpage170
dc.identifier.issn1570-1786
dc.identifier.issn1875-6255
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85042792230
dc.identifier.scopusqualityQ4
dc.identifier.startpage163
dc.identifier.urihttps://doi.org/10.2174/1570178614666170907143340
dc.identifier.urihttps://hdl.handle.net/11486/4869
dc.identifier.volume15
dc.identifier.wosWOS:000424634600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofLetters in Organic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectCrystal structure
dc.subjectfacile reaction
dc.subjectgabapentin
dc.subjectgreen synthesis
dc.subjectlactams
dc.subjectsulfonamides
dc.titleGreen and Facile Reaction of Gabapentin with Sulfonyl Chlorides to Synthesize Lactams and Sulfonamides Derivatives in Aqueous Medium
dc.typeArticle

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