Investigation of apoptotic effects of D-pantothenic acid on PC-3 prostate cancer cells

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dc.authoridAlizade, Ares/0000-0003-0334-8152
dc.contributor.authorAlizade, Ares
dc.contributor.authorOzbolat, Guluzar
dc.date.accessioned2025-03-23T19:27:38Z
dc.date.available2025-03-23T19:27:38Z
dc.date.issued2020
dc.departmentSinop Üniversitesi
dc.description.abstractPurpose: The anti-inflammatory and antioxidant properties of D-pantothenic acid have been demonstrated and the effects of dexpentanol on inflammatory pathways and apopototic pathways that trigger cell death are of interest. Apoptotic pathways are important in resistance to chemotherapeutics in cancer diseases and in cancer development. Therefore, we planned how treatment of PC-3 human prostate cancer cells with dexpanthenol will affect the levels and activities of apoptotic and inflammation mediators. For this purpose, human prostate cancer cell culture was performed. Materials and Methods: The human prostate cancer cells were treated with dexpentanaol then protein levels and activities of inflammatory and apoptotic pathway mediators such as gadd153, AIF, grp78, bax and bcl-2 in the cells were analyzed by ELISA. Results: The results of our study showed that, Dpantothenic acid did not statisticaly decreased the leves of bax, bcl-2 and grp78 protein expression in PC-3 prostate cancer cells. The effect of D-pantothenic acid on gadd153 and AIF proteins in PC-3 cells was increased but this increased level did not statisticaly significant. Conclusion: Recent studies have demonstrated the potential benefits of anti-inflammatory drugs. Our study showed that D-pantothenic acid had no significant effect on the growth of PC-3 cells and has no significant effect on intracellular apoptotic pathways.
dc.description.sponsorshipMustafa Kemal University Research Projects Unit [18.M.096]
dc.description.sponsorshipThis study was funded by Mustafa Kemal University Research Projects Unit (Project no:18.M.096).
dc.identifier.doi10.17826/cumj.736494
dc.identifier.endpage1504
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue4
dc.identifier.scopusqualityN/A
dc.identifier.startpage1499
dc.identifier.trdizinid1113725
dc.identifier.urihttps://doi.org/10.17826/cumj.736494
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1113725
dc.identifier.urihttps://hdl.handle.net/11486/4954
dc.identifier.volume45
dc.identifier.wosWOS:000609003200029
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectD-pantothenic acid
dc.subjectprostate cancer
dc.subjectdexpanthenol
dc.subjectapoptosis
dc.titleInvestigation of apoptotic effects of D-pantothenic acid on PC-3 prostate cancer cells
dc.typeArticle

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