Phthalocyanine and azaphthalocyanines containing eugenol: synthesis, DNA interaction and comparison of lipase inhibition properties

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dc.authoridSasmaz, Selami/0000-0001-5311-7550
dc.authoridFaiz, Ozlem/0000-0003-2447-0763
dc.authoridKAYA KANTAR, GUNAY/0000-0002-0259-0417
dc.contributor.authorKantar, Gunay Kaya
dc.contributor.authorFaiz, Ozlem
dc.contributor.authorSahin, Onur
dc.contributor.authorSasmaz, Selami
dc.date.accessioned2025-03-23T19:42:36Z
dc.date.available2025-03-23T19:42:36Z
dc.date.issued2017
dc.departmentSinop Üniversitesi
dc.description.abstractNovel eugenol-substituted zinc(II) azaphthalocyanines (ZnAzaPcs) were synthesised and their lipase inhibition and DNA binding properties compared with phthalocyanines (Pcs) containing eugenol. This is the first study on lipase inhibition and DNA binding of Pcs and AzaPcs containing a pharmacophore group, such as eugenol. The novel ZnAzaPcs were characterised using a combination of FT-IR, (HNMR)-H-1, (CNMR)-C-13, UV-Vis, MS and elemental analysis. The crystal structures of two pyrazine compounds were also determined by the single crystal diffraction technique. This study showed that two phthalocyanines compounds (3a and 4a) could be potential lipase inhibitor agents due to greater hydrophobicity than other azaphtalocyanines. Compound 4a displayed lowest IC50 value. Non-intercalative binding to DNA was identified only for compound 2a.
dc.description.sponsorshipRecep Tayyip Erdogan University [2014.102.02.04]
dc.description.sponsorshipThis study was supported by Recep Tayyip Erdogan University under Project No: 2014.102.02.04.
dc.identifier.doi10.1007/s12039-017-1320-4
dc.identifier.endpage1256
dc.identifier.issn0974-3626
dc.identifier.issn0973-7103
dc.identifier.issue8
dc.identifier.scopus2-s2.0-85027716961
dc.identifier.scopusqualityQ3
dc.identifier.startpage1247
dc.identifier.urihttps://doi.org/10.1007/s12039-017-1320-4
dc.identifier.urihttps://hdl.handle.net/11486/6805
dc.identifier.volume129
dc.identifier.wosWOS:000410557200016
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherIndian Acad Sciences
dc.relation.ispartofJournal of Chemical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectAzaphthalocyanine
dc.subjecteugenoe
dc.subjectlipase inhibition
dc.subjectphthalocyanine
dc.subjectDNA interaction
dc.titlePhthalocyanine and azaphthalocyanines containing eugenol: synthesis, DNA interaction and comparison of lipase inhibition properties
dc.typeArticle

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