Computational design and fabrication of a highly selective and sensitive molecularly imprinted electrochemical sensor for the detection of enzalutamide

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dc.authoridBellur Atici, Esen/0000-0002-4093-441X
dc.authoridCetinkaya, Ahmet/0000-0001-5014-0907
dc.authoridCorman, Mehmet Emin/0000-0001-9062-4201
dc.authoridKarakaya, Mustafa/0000-0001-6663-9008
dc.authoridOZKAN, Sibel/0000-0001-7494-3077
dc.contributor.authorKaya, S. Irem
dc.contributor.authorCetinkaya, Ahmet
dc.contributor.authorOzcelikay, Goksu
dc.contributor.authorCorman, M. Emin
dc.contributor.authorKarakaya, Mustafa
dc.contributor.authorAtici, Esen Bellur
dc.contributor.authorOzkan, Sibel A.
dc.date.accessioned2025-03-23T19:41:12Z
dc.date.available2025-03-23T19:41:12Z
dc.date.issued2022
dc.departmentSinop Üniversitesi
dc.description.abstractThis study demonstrates the first electrochemical analysis of an anti-androgen drug enzalutamide with a molecularly imprinted polymer (MIP)-based sensor. An electrochemical sensor was developed through computational approaches for screening functional monomers in the rational design of MIPs. Based on the computational approach, ortho-phenylenediamine (o-PD) was selected as a functional monomer based on the comparison of interaction energies (Delta E) between enzalutamide and monomers. The characterization of the MIP-based sensor was investigated by Raman spectroscopy, surface electron microscopy (SEM), contact angle measurements, and electrochemical techniques. Different electrochemical techniques such as differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) were utilized for the evaluation of MIP parameters (removal process, incubation time, monomer ratio etc.). MIP@ANI-co-o-PD/GCE showed a linear response in the concentration range between 1 x 10(-16) M and 1 x 10(-15) M with the limit of detection (LOD) and limit of quantification (LOQ) values of 0.019 fM and 0.065 fM, respectively. The application studies from human serum and pharmaceutical dosage form samples were concluded with good recovery results demonstrating the sensor's applicability, selectivity, precision, and accuracy. Furthermore, selectivity studies were carried out with similarly structured compounds teriflunomide and leflunomide. Lastly, the non-imprinted polymer (NIP) based electrochemical sensor was prepared and used for the performance evaluation of the MIP@ANI-co-o-PD/GCE sensor.
dc.description.sponsorshipCouncil of Higher Education 100/2000 (YOK) [100/2000]; Scientific and Technological Research Council of Turkey (TUBI-TAK); Scientific and Technological Research Coun-cil of Turkey (TuBITAK) under the BIDEB/2218-National Postdoctoral Research Fellowship Program for Turkish Citizens
dc.description.sponsorshipAhmet Cetinkaya thanks the financial supports from Council of Higher Education 100/2000 (YOK) under the special 100/2000 and the Scientific and Technological Research Council of Turkey (TUBI-TAK) under the BIDEB/2211-A PhD Scholarship Programmes. Mehmet Emin Corman thanks the Scientific and Technological Research Coun-cil of Turkey (TuBITAK) under the BIDEB/2218-National Postdoctoral Research Fellowship Program for Turkish Citizens.
dc.identifier.doi10.1016/j.jelechem.2022.116030
dc.identifier.issn1572-6657
dc.identifier.issn1873-2569
dc.identifier.scopus2-s2.0-85123020787
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jelechem.2022.116030
dc.identifier.urihttps://hdl.handle.net/11486/6522
dc.identifier.volume907
dc.identifier.wosWOS:000767881100010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofJournal of Electroanalytical Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectEnzalutamide
dc.subjectMolecularly imprinted polymer
dc.subjectAniline
dc.subjectO-phenylenediamine
dc.subjectElectrochemical determination
dc.subjectVoltammetry
dc.subjectDrug analysis
dc.titleComputational design and fabrication of a highly selective and sensitive molecularly imprinted electrochemical sensor for the detection of enzalutamide
dc.typeArticle

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