Synthesis and cytotoxic activities of organometallic Ru(II) diamine complexes

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dc.authoridKendirci-Katirci, Remziye/0000-0002-6839-8823
dc.authoridKavukcu, Serdar Batikan/0000-0002-1168-5012
dc.authoridPelit, Levent/0000-0001-8090-703X
dc.authoridKorkmaz, Mehmet/0000-0003-1058-5586
dc.contributor.authorKavukcu, Serdar Batikan
dc.contributor.authorSahin, Onur
dc.contributor.authorVatansever, Hafize Seda
dc.contributor.authorKurt, Feyzan Ozdal
dc.contributor.authorKorkmaz, Mehmet
dc.contributor.authorKendirci, Remziye
dc.contributor.authorPelit, Levent
dc.date.accessioned2025-03-23T19:41:57Z
dc.date.available2025-03-23T19:41:57Z
dc.date.issued2020
dc.departmentSinop Üniversitesi
dc.description.abstractA series of mono and bimetallic ruthenium(II) arene complexes bearing diamine (Ru1-6) were prepared and fully characterized by H-1, C-13, F-19, and P-31 NMR spectroscopy and elemental analysis. The crystal structure of the bimetallic complex (Ru-5) was determined by X-ray crystallography. Monometallic analogues (Ru1-3) were synthesized to investigate the contributions of ruthenium and the other organic groups (aren, ethylenediamine, butyl) to the activity. The electrochemical behaviors of mono and bimetallic complexes were obtained from the relationship between cyclic voltammetry (CV) and the biological activities of the compounds. The cytotoxic activities of the complexes (Ru1-6) were tested against wide-scale cancer cell lines, namely HeLa, MDA-MB-231, DU-145, LNCaP, Hep-G2, Saos-2, PC-3, and MCF-7, and normal cell lines 3T3-L1 and Vero. Diamine Ru(II) arene complexes have unique biological characteristics and they are promising models for new anticancer drug development. MTT analysis reveals that each synthesized Ru complex showed cytotoxic activity towards the different cancer cells. In particular, three Ru complexes (Ru-3, Ru-5 and Ru-6) showed less toxic effects on the cancer cells than the others. These novel Ru complexes affected both cancer and normal cell lines. As they had a toxic effect on the cells, the dosage applied should be tested before being used for in vivo applications. Cytotoxicity tests have shown that the bimetallic complex Ru-6 was effective on all cancer cells. The effect of bimetallic enhancement on cancer cell lines, the systematic variation of the intermetallic distance and the ligand donor properties of the mono and bimetallic complexes were explored based on the cytotoxic activity. The interaction with FS-DNA and the stability/aquation of the complexes (Ru-3 and Ru-6) were investigated with H-1 NMR spectroscopy. The binding modes between the complexes (Ru-3 and Ru-6) and DNA were investigated via UV-Vis spectroscopy.
dc.description.sponsorshipEge University [17-FEN-042]; Scientific and Technological Research Council of Turkey (TUBITAK) [214Z098]
dc.description.sponsorshipThe authors thank Ege University (Project Number: 17-FEN-042) and the Scientific and Technological Research Council of Turkey (TUBITAK, Project Number: 214Z098) for their financial support. The authors acknowledge the Scientific and Technological Research Application and Research Center, Sinop University, Turkey, for the use of the Bruker D8 QUEST diffractometer.
dc.identifier.doi10.1016/j.bioorg.2020.103793
dc.identifier.issn0045-2068
dc.identifier.issn1090-2120
dc.identifier.pmid32278205
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2020.103793
dc.identifier.urihttps://hdl.handle.net/11486/6687
dc.identifier.volume99
dc.identifier.wosWOS:000535439200008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofBioorganic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectRuthenium(II) arene complex
dc.subjectCancer
dc.subjectCytotoxicity
dc.subjectBimetallic complex
dc.titleSynthesis and cytotoxic activities of organometallic Ru(II) diamine complexes
dc.typeArticle

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