The effect of thrombosis-related laboratory values on mortality in COVID-19 infection

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dc.authoridKaya, Tezcan/0000-0003-0483-2333
dc.authoridGunay, Serkan/0000-0002-8343-0916
dc.authoridTor, Ibrahim Hakki/0000-0003-0246-3220
dc.authoridnalbant, ahmet/0000-0003-4756-3575
dc.contributor.authorErgenc, Z.
dc.contributor.authorErgenc, H.
dc.contributor.authorOzturk, A.
dc.contributor.authorKaya, T.
dc.contributor.authorNalbant, A.
dc.contributor.authorKaracaer, C.
dc.contributor.authorGunay, S.
dc.date.accessioned2025-03-23T19:48:50Z
dc.date.available2025-03-23T19:48:50Z
dc.date.issued2023
dc.departmentSinop Üniversitesi
dc.description.abstractOBJECTIVE: COVID-19 may cause thrombosis in both venous and arterial systems. Familiarity with the signs and symp-toms of thrombosis and its treatment is essen-tial in treating COVID-19 infection and its com-plications. D-Dimer and mean platelet volume (MPV) are measurements related to the devel-opment of thrombosis. This study investigates whether MPV and D-Dimer values could be used to determine the risk of thrombosis and mortali-ty in the COVID-19 early stages.PATIENTS AND METHODS: 424 patients who were COVID-19 positive, according to the World Health Organization (WHO) guidelines, were randomly and retrospectively included in the study. Demographic and clinical character-istics such as age, gender, and length of hospi-talization were obtained from the digital records of participants. Participants were divided into living and deceased groups. The patients' bio-chemical, hormonal, and hematological param-eters were analyzed retrospectively.RESULTS: White blood cells (WBC), neutro-phils, and monocytes were significantly differ-ent in the two groups (p-value <0.001), and their values were lower in the living group than in the deceased group. MPV median values did not dif-fer according to prognosis (p-value = 0.994). While the median value was 9.9 in the survivors, it was 10 in the deceased. Creatinine, procalci-tonin, ferritin, and the number of hospitalization days in living patients were significantly lower than in patients who died (p-value <0.001). Me-dian values of D-dimer (mg/L) differ according to prognosis (p-value <0.001). While the median value was 0.63 in the survivors, it was found as 438 in the deceased.CONCLUSIONS: Our results did not show any significant relationship between the mortality of COVID-19 patients and their MPV levels. How-ever, a significant association between D-Di-mer and mortality in COVID-19 patients was ob-served.
dc.identifier.endpage2705
dc.identifier.issn1128-3602
dc.identifier.issue6
dc.identifier.pmid37013789
dc.identifier.scopusqualityQ2
dc.identifier.startpage2699
dc.identifier.urihttps://hdl.handle.net/11486/7668
dc.identifier.volume27
dc.identifier.wosWOS:000973400100014
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectCOVID-19
dc.subjectMPV
dc.subjectD-Dimer
dc.subjectPrognosis
dc.subjectMortality
dc.titleThe effect of thrombosis-related laboratory values on mortality in COVID-19 infection
dc.typeArticle

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