A square planar cobalt(II)-thiosemicarbazone complex. Synthesis, characterization, antiviral and anti-inflammatory potential

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dc.authoridSahin, Onur/0000-0003-3765-3235
dc.authoridKaya, Busra/0000-0003-2706-172X
dc.authoridULKUSEVEN, BAHRI/0000-0001-6342-1505
dc.contributor.authorAtasever-Arslan, Belkis
dc.contributor.authorKaya, Busra
dc.contributor.authorSahin, Onur
dc.contributor.authorUlkuseven, Bahri
dc.date.accessioned2025-03-23T19:39:18Z
dc.date.available2025-03-23T19:39:18Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractConsidering the possible antiviral effect of cobalt compounds and known pharmacological potential of thiosemicarbazones, a new combination containing cobalt(II) ions and tetradentate thiosemicarbazone was synthesized and structurally analyzed. In the complex structure (Co1), the cobalt ion is in 2+ + oxidation state and is coordinated with ONNO donor set on the thiosemicarbazone backbone. The complex molecule crystallizes in the space group P21/m and the environment of the cobalt center tends to square planar geometry. The inhibitory performance of SARS-CoV-2 and the anti-inflammatory impact of the complex molecule were investigated. It was found that Co1 has high inhibitory effects on the SARS-CoV-2 virus's 3CL main protease enzyme, ACE2:SARSCoV2 Spike RBD interaction, and IL8. Also, it showed significant anti-inflammatory effects on the release of IL6, IL8, IL10, and TGF beta 1 beta 1 cytokines and wound healing during in vitro TNF-alpha-induced inflammation. Experimental evidence demonstrates that Co1 diminishes both IL8 gene expression and protein levels. According to in silico and experimental results, it has a drug potential. Assessing the in vivo impacts of Co1 might contribute to understanding its potential as an antiviral and anti-inflammatory agent.
dc.description.sponsorshipHealth Institutes of Turkiye [24482]
dc.description.sponsorshipThere is no conflict of interest for the writers. The authors acknowledge the Scientific and Technological Research Application and Research Center at Sinop University, Turkey, for their use of the Bruker D8 QUEST diffractometer. This study was partially funded by the Health Institutes of Turkiye (Project Number: 24482) .
dc.identifier.doi10.1016/j.molstruc.2024.140109
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85204729566
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2024.140109
dc.identifier.urihttps://hdl.handle.net/11486/6313
dc.identifier.volume1321
dc.identifier.wosWOS:001322209000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectSARS-CoV-2
dc.subjectInflammation
dc.subjectIL8
dc.subjectThiosemicarbazone
dc.subjectCobalt
dc.subjectCOVID19
dc.titleA square planar cobalt(II)-thiosemicarbazone complex. Synthesis, characterization, antiviral and anti-inflammatory potential
dc.typeArticle

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