Synthesis, characterization, and use of lanthanide chelate of β-diketonate based ligand as a luminescent biolabel

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dc.contributor.authorYuvayapan, Semanur Sen
dc.contributor.authorColak, Alper Tolga
dc.contributor.authorSahin, Onur
dc.contributor.authorCelik, Cumali
dc.date.accessioned2025-03-23T19:16:58Z
dc.date.available2025-03-23T19:16:58Z
dc.date.issued2021
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, we aimed to synthesize a β-diketonate-based ligand and its Eu(III) complex which are used for luminescent biolabel. For this purpose, we chose acetophenone as the starting material which contains methyl group at the alpha position of the ketone group. Firstly, we obtained 4,4,5,5,6,6,7,7-octafluoro-3,8-dihydroxy-1,10-diphenyldeca-2,8-diene-1,10-dione (H2ODIT) ligand in a reaction between acetophenone and diethyloctafluoroadipate with Claisen condensation. This ligand was characterized by1H-NMR,13C-NMR, and mass spectral analyses. We obtained a single crystal H2ODIT as characterized by X-ray analysis. At the second step, in order to bind H 2ODIT to the antibody, it is reacted with chlorosulfonic acid. As a result of this reaction, the functional group of-ClSO2 was bound to the structure. The structure of H2CODIT was characterized by NMR and mass spectral analysis. In the third step, to understand the usability of the ligand as a biolabel, the complex compound was synthesized with EuCl3. The complex compound was excited with UV light at 306 nm wavelength, specific hypersensitive5D0 →7F2 phosphorescence electronic transition of the Eu(III) was observed which proved that the luminescent H2CODIT molecule can work as a biolabel. © 2021, Turkish Chemical Society. All rights reserved.
dc.description.sponsorshipTÜBİTAK
dc.identifier.doi10.18596/jotcsa.949970
dc.identifier.endpage850
dc.identifier.issn2149-0120
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85114036018
dc.identifier.scopusqualityQ3
dc.identifier.startpage835
dc.identifier.trdizinid451079
dc.identifier.urihttps://doi.org/10.18596/jotcsa.949970
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/451079
dc.identifier.urihttps://hdl.handle.net/11486/4235
dc.identifier.volume8
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTurkish Chemical Society
dc.relation.ispartofJournal of the Turkish Chemical Society, Section A: Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250323
dc.subjectBeta-diketonate
dc.subjectBiolabel
dc.subjectClaisen condensation
dc.subjectEuropium(III) complex
dc.subjectKeto-enol tautomerism
dc.subjectLuminescence
dc.titleSynthesis, characterization, and use of lanthanide chelate of β-diketonate based ligand as a luminescent biolabel
dc.typeArticle

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