Comparative Study on Phytochemical Profiles, Antiproliferative, Antimicrobial and Antioxidant Activities of Adonis Species from Turkey

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dc.authoridTURKMEN, Musa/0000-0001-9914-9523
dc.authoridAvsar, cumhur/0000-0002-4095-0022
dc.contributor.authorKarahan, Faruk
dc.contributor.authorAvsar, Cumhur
dc.contributor.authorTurkmen, Musa
dc.contributor.authorGezici, Sevgi
dc.contributor.authorIlcim, Ahmet
dc.date.accessioned2025-03-23T19:44:07Z
dc.date.available2025-03-23T19:44:07Z
dc.date.issued2022
dc.departmentSinop Üniversitesi
dc.description.abstractThe present study aimed to determine antiproliferative, antimicrobial, antioxidant activities and also phytochemical composition of different nine Adonis L. species from Turkey. Leaves extracts of the plant samples were used to evaluate antimicrobial activity against 7 bacteria and 2 yeast strains using MICs and disc-diffusion methods. The antioxidant activity of plant samples was determined by using DPPH radical scavenging activity method. MTT assay was used for evaluation antiproliferative activities of the extracts against HL-60, HCA-7 and HUVEC human cells. Chemical composition of plant extracts were determined by Gas Chromatography/Mass Spectrometry. The antimicrobial analyses results showed Gram-negative bacteria more sensitive than Gram-positive against the extracts, and the values were varied from 3.1 to 13.4 mu g/mL. The leaf extract of different Adonis species exhibited remarkable antiproliferative activities towards tested human cancer cells in a dose and time dependently, and they were found to possess more antiproliferative activity against HL-60 cells than that of the HCA-7 cells. As for the chemical composition of Adonis species, they were found to contain many components with antimicrobial and beneficial effects, such as ethyl palmitate, ethyl linoleate. Overall, it was concluded that leaves extracts of Adonis species could have a great potential for use in medicinal drug sources.
dc.identifier.doi10.1007/s11094-022-02693-0
dc.identifier.endpage678
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85136209318
dc.identifier.scopusqualityQ4
dc.identifier.startpage667
dc.identifier.urihttps://doi.org/10.1007/s11094-022-02693-0
dc.identifier.urihttps://hdl.handle.net/11486/6876
dc.identifier.volume56
dc.identifier.wosWOS:000842587200004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPharmaceutical Chemistry Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectchemical composition
dc.subjectGC-MS
dc.subjectbiological activity
dc.subjectmedicinal plant
dc.subjectcell death
dc.subjectantiproliferative
dc.titleComparative Study on Phytochemical Profiles, Antiproliferative, Antimicrobial and Antioxidant Activities of Adonis Species from Turkey
dc.typeArticle

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