Antenna-type radiofrequency generator in nanoparticle-mediated hyperthermia

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dc.authoridNasseri, Behzad/0000-0003-3634-8327
dc.authoridyilmaz, mehmet/0000-0003-2687-9167
dc.contributor.authorNasseri, B.
dc.contributor.authorYilmaz, M.
dc.contributor.authorTurk, M.
dc.contributor.authorKocum, I. C.
dc.contributor.authorPiskin, E.
dc.date.accessioned2025-03-23T19:35:43Z
dc.date.available2025-03-23T19:35:43Z
dc.date.issued2016
dc.departmentSinop Üniversitesi
dc.description.abstractInduction of hyperthermia using nanoparticles with specific magnetic, electrical, acoustic, optical or thermal properties is a potential alternative to conventional thermal ablation in cancer therapy. In this study, for the first time we employed an antenna-type radiofrequency (RF) generator as the energy source and as a proof of concept the effects of nanoparticles of varying structures and sizes, such as super-paramagnetic iron oxide nanoparticles (SPIONs), gold-coated superparamagnetic iron oxide nanoparticles (Au@SPIONs), spherical gold nanoparticles (AuNPs), and gold nanorods (AuNRs) on RF hyperthermia were examined to determine hyperthermia efficiency of the antenna-type RF generator. In preliminary experiments, RF was applied at varying powers to various nanoparticle solutions. In all cases, temperature rises due to exposure of RF radiation to nanoparticles were captured by using an infrared thermal camera. This procedure was applied to in vitro tests of fibroblast (L-929) and breast cancer (MCF-7) cell lines. Cell viability, apoptosis and necrosis were evaluated in both cell lines to comprehensively determine cell toxicity. Due to their particle size and chemical nature, SPIONs, in the case of highest RF power and nanoparticle concentration, resulted in the lowest cell viability and highest levels of apoptosis and necrosis.
dc.description.sponsorshipTurkish Academy of Science
dc.description.sponsorshipEP also acknowledges support from the Turkish Academy of Science as a full member. The authors also wish to thank the Department of Molecular Biology and Genetics (Bilkent University, Turkey) and the Sap Institute (Ankara, Turkey) for supplying the cell lines.
dc.identifier.doi10.1039/c6ra03197h
dc.identifier.endpage48434
dc.identifier.issn2046-2069
dc.identifier.issue54
dc.identifier.scopus2-s2.0-84971328545
dc.identifier.scopusqualityQ1
dc.identifier.startpage48427
dc.identifier.urihttps://doi.org/10.1039/c6ra03197h
dc.identifier.urihttps://hdl.handle.net/11486/5918
dc.identifier.volume6
dc.identifier.wosWOS:000377257000021
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofRsc Advances
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectGold Nanoparticles
dc.subjectCell-Death
dc.subjectDestruction
dc.subjectAblation
dc.subjectTherapy
dc.subjectTime
dc.titleAntenna-type radiofrequency generator in nanoparticle-mediated hyperthermia
dc.typeArticle

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