Novel silver(I) complexes bearing mefenamic acid and pyridine derivatives: Synthesis, chemical characterization and in vitro anticancer evaluation

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dc.authoridSAHIN, ZARIFE SIBEL/0000-0003-2745-7871
dc.contributor.authorAltay, Ahmet
dc.contributor.authorCaglar, Sema
dc.contributor.authorCaglar, Bulent
dc.contributor.authorSahin, Zarife Sibel
dc.date.accessioned2025-03-23T19:41:30Z
dc.date.available2025-03-23T19:41:30Z
dc.date.issued2019
dc.departmentSinop Üniversitesi
dc.description.abstractTwo Ag(I) complexes [Ag-2(mu-mef)(2)(2-pymet)(2)]1, [Ag-2(mu-mef)(2)(2-Pyet)(2)](2) containing mefenamic acid, 2-pyridinemethanol and 2-pyridineethanol were synthesized and characterized by using SCXRD, FT-IR, elemental and thermal analysis techniques. The complex 1 was synthesized as a single crystal whereas the complex 2 was obtained as a microcrystalline powder. The complex 1 consists of binuclear structure. The argentophilic interaction occurs among silver(I) ions due to the short Ag center dot center dot center dot Ag distance (2.8710(10) angstrom). Two Ag(I) centers are connected by carboxylato oxygen-bridge to form the binuclear metal core. The FT-IR spectra and thermal analysis studies confirmed that both complexes exhibited similar structures. In vitro antiproliferative activity of both complexes were evaluated against MCF-7, HT-29 and HepG2 cancer cell lines. The apoptotic effects and intracellular ROS generation from both complexes were investigated in MCF-7 cell line by flow cytometry analysis. The XTT and LDH assays revealed that both complexes showed strong antiproliferative activity with higher selectivity towards cancer cells compared to the normal cells. In addition, Annexin V/propidium iodide assay exhibited that apoptotic cell number was increased in MCF-7 cells with increasing concentrations of Ag(I) complexes. Furthermore, both complexes induced the ROS generation considerably in MCF-7 cells suggesting the possible pro-oxidant activity of the novel synthesized Ag(I) complexes. Taken together, these findings provide a notable support for potential utility of Ag(I) complexes as novel anticancer agents against numerous kind of carcinogenesis.
dc.identifier.doi10.1016/j.ica.2019.05.008
dc.identifier.endpage71
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-85065844355
dc.identifier.scopusqualityQ2
dc.identifier.startpage61
dc.identifier.urihttps://doi.org/10.1016/j.ica.2019.05.008
dc.identifier.urihttps://hdl.handle.net/11486/6599
dc.identifier.volume493
dc.identifier.wosWOS:000471754200009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofInorganica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectMefenamic acid
dc.subjectSilver(I) complex
dc.subjectCell culture
dc.subjectAntiproliferative activity
dc.subjectFlow cytometry analysis
dc.titleNovel silver(I) complexes bearing mefenamic acid and pyridine derivatives: Synthesis, chemical characterization and in vitro anticancer evaluation
dc.typeArticle

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