Efficient Syntheses, Crystal Structure and Thermal Properties of Gabapentin 4-Acetamido, 2-Mesitylene and 2,4-Dinitro Sulfonamides Derivatives

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dc.contributor.authorKanwal, Nosheen
dc.contributor.authorKhan, Islam Ullah
dc.contributor.authorSharif, Shahzad
dc.contributor.authorHussain, Erum Akbar
dc.contributor.authorMehmood, Arshad
dc.contributor.authorSahin, Onur
dc.date.accessioned2025-03-23T19:44:16Z
dc.date.available2025-03-23T19:44:16Z
dc.date.issued2019
dc.departmentSinop Üniversitesi
dc.description.abstractEfficient syntheses of four derivatives G2-G5 of Gabapentin (G1) have been achieved. The structures of targeted compounds were investigated by elemental analysis, FT-IR, and H-1-NMR spectroscopic method. Crystal structures of G2 and G4 determined by single crystal X-ray diffraction method are also described. In G2 the molecules are stacked over each other in the form of layers and adjacent layers run parallel to each other. Intermolecular hydrogen bonding and van der Waals interactions are responsible for building the molecular assembly and packing of molecules in the unit. In G4, the molecules are arranged in parallel sheets formed by inter-molecular hydrogen bonds. The proposed synthetic route has high impact due to its simple reaction conditions of room temperature, water as a green solvent and short time to accomplish the reaction.
dc.identifier.doi10.1007/s10870-018-00765-2
dc.identifier.endpage168
dc.identifier.issn1074-1542
dc.identifier.issn1572-8854
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85059504967
dc.identifier.scopusqualityQ3
dc.identifier.startpage162
dc.identifier.urihttps://doi.org/10.1007/s10870-018-00765-2
dc.identifier.urihttps://hdl.handle.net/11486/6914
dc.identifier.volume49
dc.identifier.wosWOS:000485397200006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofJournal of Chemical Crystallography
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectGabapentin
dc.subjectSulfonamides
dc.subjectSynthesis
dc.subjectCrystal structure
dc.subjectThermal analysis
dc.titleEfficient Syntheses, Crystal Structure and Thermal Properties of Gabapentin 4-Acetamido, 2-Mesitylene and 2,4-Dinitro Sulfonamides Derivatives
dc.typeArticle

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