Iron(III) complexes based on tetradentate thiosemicarbazones: Synthesis, characterization, radical scavenging activity and in vitro cytotoxicity on K562, P3HR1 and JURKAT cells

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dc.authoridULKUSEVEN, BAHRI/0000-0001-6342-1505
dc.authoridBAL-DEMIRCI, Tulay/0000-0003-4663-2209
dc.contributor.authorKalindemirtas, Ferdane Danisman
dc.contributor.authorKaya, Busra
dc.contributor.authorBener, Mustafa
dc.contributor.authorSahin, Onur
dc.contributor.authorKuruca, Serap Erdem
dc.contributor.authorDemirci, Tulay Bal
dc.contributor.authorUlkuseven, Bahri
dc.date.accessioned2025-03-23T19:47:17Z
dc.date.available2025-03-23T19:47:17Z
dc.date.issued2021
dc.departmentSinop Üniversitesi
dc.description.abstractNine iron(III) complexes, [Fe(L)Cl], were synthesized starting from S-alkyl-thiosemicarbazones and some substituted aldehydes. The L ligands formed by template condensation are N2O2-chelating structures and named N-1-acetylacetone-N-4-R-salicylidene-S-alkyl-thiosemicarbazidato (L2-) where alkyl = methyl, propyl, or allyl and R = 3-methoxy, 4-methoxy, or 3,5-dichloro. The complexes were characterized using elemental analysis, IR, and ESI-MS. X-ray diffraction analysis of complex Fe8 (as a representative sample) indicated a square pyramid environment of the iron ion. The cytotoxicity performances of the complexes were determined using chronic myelogenous leukemia (K562), Burkitt's lymphoma (P3HR1), and T-cell leukemia (JURKAT) cell lines. For comparison, the noncancerous cell lines, human umbilical vein endothelial (HUVEC) and diploid fibroblast (3T3), and imatinib as positive control were included in the study. MTT results revealed that complexes Fe2, Fe5, Fe7, and Fe8 with methoxy (OCH3) substituent have remarkable cytotoxic effects on K562 and P3HR1 cells at relatively low concentrations in the ranges of 4.81-14.05 and 5.61-11.98 mu M, respectively. The radical scavenging activities of the complexes were measured for DPPH, superoxide anion (O-2(center dot-)), hydroxyl (center dot OH) radicals, and hydrogen peroxide (H2O2). Complexes Fe2, Fe3, Fe5, and Fe8, which exhibited selective cytotoxicity, were able to compete also with vitamin E in terms of ROS scavenging activities.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa [24436]; TUBITAK [214Z073]
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa, Grant/Award Number: 24436; TUBITAK, Grant/Award Number: 214Z073
dc.identifier.doi10.1002/aoc.6157
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85099027417
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/aoc.6157
dc.identifier.urihttps://hdl.handle.net/11486/7326
dc.identifier.volume35
dc.identifier.wosWOS:000604898100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofApplied Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectantioxidant
dc.subjectcytotoxicity
dc.subjectiron(III)
dc.subjectradical scavenging
dc.subjectthiosemicarbazone
dc.titleIron(III) complexes based on tetradentate thiosemicarbazones: Synthesis, characterization, radical scavenging activity and in vitro cytotoxicity on K562, P3HR1 and JURKAT cells
dc.typeArticle

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