New Copper and Cobalt Complexes Based on a Fluorinated Pyrazole Derivative, Synthesis, Characterization and Antibacterial Activity

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dc.contributor.authorAmin, Mina A.
dc.contributor.authorDiker, Halide
dc.contributor.authorSahin, Onur
dc.contributor.authorVarlikli, Canan
dc.contributor.authorSoliman, Ahmed A.
dc.date.accessioned2026-04-25T14:18:57Z
dc.date.available2026-04-25T14:18:57Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractTwo copper and cobalt complexes based on 3-(trifluoromethyl)-4-((3-(trifluoromethyl)phenyl)diazenyl)-1H-pyrazol-5-ol (Httdp) have been prepared and characterized using different physicochemical techniques. The crystal structure of the copper complex has been proven to be a square pyramidal, and the cobalt complex has an octahedral structure. DFT calculations of the complexes were performed, and the energy gaps between the HOMO-LUMO of the complexes (-3.38676 to -3.18138 eV) and the Cu (II) complex reflect a higher relative stability compared with Httdp and the Co (II) complex. The antibacterial activities of the two complexes were evaluated. The Co (II) complex demonstrated the highest antibacterial activity against various bacteria compared with Httdp and the Cu (II) complex. The mean inhibition zones exhibited by the Co (II) complex showed the highest activities toward the Gram-negative bacterial strains with mean inhibition zones of 30.3 +/- 0.6 (Staphylococcus aureus) and 25.7 +/- 0.6 (Bacillus subtilis) mm. Docking studies were carried out using S. aureus tyrosyl-tRNA synthetase (PDB ID: 1JIJ) to assess the antimicrobial activities, proving that the complexes were efficient for the protein.
dc.description.sponsorshipPresidency of the Turkish Republic Department of Strategy and Budget; [2016K12-2841]
dc.description.sponsorshipThe authors would also like to dedicate the work to the late Professor Hussein F. Zohdi, Professor of organic chemistry, at the Faculty of Science, Cairo University, Egypt, who passed away multiple years ago before starting the project. The authors acknowledge the Presidency of the Turkish Republic Department of Strategy and Budget (Project Grant No.: 2016K12-2841) for the financial support to conduct the photoluminescence and electrochemical analyses.
dc.identifier.doi10.1002/aoc.70140
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue5
dc.identifier.orcid0000-0002-8805-8009
dc.identifier.scopus2-s2.0-105002174482
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/aoc.70140
dc.identifier.urihttps://hdl.handle.net/11486/8125
dc.identifier.volume39
dc.identifier.wosWOS:001461612400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofApplied Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260420
dc.subjectantimicrobial activities
dc.subjectcopper and cobalt complexes
dc.subjectin silico studies
dc.subjectpyrazole
dc.titleNew Copper and Cobalt Complexes Based on a Fluorinated Pyrazole Derivative, Synthesis, Characterization and Antibacterial Activity
dc.typeArticle

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