Determination of Trace Element Concentrations in Blood Samples and Their Correlation to Breast Cancer

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dc.authoridtopdagi, omer/0000-0002-9690-4447
dc.authoridTOKER, OZAN/0000-0002-5566-0298
dc.authoridDemir, Mustafa/0000-0002-9813-1628
dc.contributor.authorTopdagi, Omer
dc.contributor.authorToker, Ozan
dc.contributor.authorBakirdere, Sezgin
dc.contributor.authorOz, Ersoy
dc.contributor.authorBursalioglu, Ertugrul Osman
dc.contributor.authorAbuqbeitah, Mohammad
dc.contributor.authorDemir, Mustafa
dc.date.accessioned2025-03-23T19:25:45Z
dc.date.available2025-03-23T19:25:45Z
dc.date.issued2020
dc.departmentSinop Üniversitesi
dc.description.abstractThe main purpose of this study was to investigate the possible differences in the concentrations of Al, Cu, Ca, Mg, Fe, Ni, and Pb in breast cancer patients and healthy control group. One blood sample each was collected from 40 adult female patients diagnosed with breast cancer and 40 healthy adult female individuals with no medical history of cancer. The concentrations of the elements Al, Cu, Fe, Ni, and Pb were determined by ICP-MS, while Ca and Mg were determined by ICP-OES. Statistical analysis was performed with the Kolmogorov-Smirnov normality test, the Mann-Whitney U test, and the Spearman's rank correlation test. It was observed that the concentrations of Cu and Mg in the breast cancer patients were significantly higher (p=0.000<0.05 and p=0.001<0.05, respectively) than for the healthy group, while the Al concentration was significantly lower (p=0.002<0.05) in the cancer patients. The Mg concentration in the control group and the patients was 33.60 +/- 4.51 and 38.10 +/- 9.69 mg/kg, respectively. The difference was statistically significant for Cu, Mg, and Al, whereas no difference was observed between the concentrations of Ca and Fe. Furthermore, a positive correlation was observed in breast cancer patients between the concentrations of (Al-Cu), (Al-Ca), (Fe-Mg), and (Cu-Ca).
dc.description.sponsorshipTUBITAK [2210C]; Yildiz Technical University BAP [2015-01-01-YL04, 832]
dc.description.sponsorshipThis study was funded by TUBITAK (2210C) and Yildiz Technical University BAP (2015-01-01-YL04, 832).
dc.identifier.doi10.46770/AS.2020.01.004
dc.identifier.endpage35
dc.identifier.issn0195-5373
dc.identifier.issn2708-521X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85084033988
dc.identifier.scopusqualityQ2
dc.identifier.startpage29
dc.identifier.urihttps://doi.org/10.46770/AS.2020.01.004
dc.identifier.urihttps://hdl.handle.net/11486/4559
dc.identifier.volume41
dc.identifier.wosWOS:000521635300004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAtomic Spectroscopy Press Ltd
dc.relation.ispartofAtomic Spectroscopy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectCopper
dc.subjectSerum
dc.subjectCalcium
dc.subjectIron
dc.subjectZinc
dc.titleDetermination of Trace Element Concentrations in Blood Samples and Their Correlation to Breast Cancer
dc.typeArticle

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