Should Screening for Colorectal Neoplasm Be Recommended in Patients at High Risk for Coronary Heart Disease A Cross-Sectional Study

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dc.contributor.authorBasyigit, Sebahat
dc.contributor.authorOzkan, Selcuk
dc.contributor.authorUzman, Metin
dc.contributor.authorErtugrul, Derun T.
dc.contributor.authorKefeli, Ayse
dc.contributor.authorAktas, Bora
dc.contributor.authorYeniova, Abdullah O.
dc.date.accessioned2025-03-23T19:34:18Z
dc.date.available2025-03-23T19:34:18Z
dc.date.issued2015
dc.departmentSinop Üniversitesi
dc.description.abstractColorectal neoplasm (CRN) and coronary heart disease (CHD) share common risk factors. We aimed to assess the risk for CRN in patients who are at high risk for developing CHD determined by measurements, which are independent from the risk factors for CRN. This study was conducted on individuals who underwent total colonoscopic examination and were without history of CHD. Two-hundred thirty-five subjects (82 with CRN and 153 with normal colonoscopic findings) participated in the study. Colorectal carcinoma (CRC) was defined as the presence of adenocarcinoma. We measured carotid intima media thickness (CIMT), flow-mediated dilation (FMD), and calculated Framingham risk score (FRS) for all participants. An increased CIMT (>= 1.0mm), a decreased FMD (<10%), and a high FRS (>20%) were defined as high risks for developing CHD. The risk and the prevalence of CRN were analyzed in relation to the risk for developing CHD. The ratio of the patients with overall-CRN and CRC was significantly higher in individuals who are at high risk for developing CHD compared with individuals who are at low risk for developing CHD by each 3 risk estimation method (P<0.05 for all). An increased CIMT, a decreased FMD, and a high FRS score were significantly associated with the high risk for the presence of CRC (odds ratio [OR]: 6.018, OR: 3.699, and OR: 4.120, respectively). An increased CIMT, a decreased FMD, and an intermediate FRS were significantly associated with the risk for the presence of overall-CRN (OR: 3.607, OR: 1.866 and OR: 2.889, respectively). The risk for CRN increases as the risk for developing CHD increases. It can be suggested that screening for CRN can be recommended for individuals who are at high risk for developing CHD.
dc.identifier.doi10.1097/MD.0000000000000793
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue20
dc.identifier.pmid25997050
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000000793
dc.identifier.urihttps://hdl.handle.net/11486/5646
dc.identifier.volume94
dc.identifier.wosWOS:000354984600016
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMedicine
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectIntima-Media Thickness
dc.subjectMetabolic Syndrome
dc.subjectPhysical-Activity
dc.subjectColon-Cancer
dc.subjectArtery
dc.subjectInsulin
dc.subjectObesity
dc.subjectGuidelines
dc.subjectManagement
dc.subjectNutrition
dc.titleShould Screening for Colorectal Neoplasm Be Recommended in Patients at High Risk for Coronary Heart Disease A Cross-Sectional Study
dc.typeReview

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