A Novel DNA Biosensor Based on a Pencil Graphite Electrode Modified with Polypyrrole/Functionalized Multiwalled Carbon Nanotubes for Determination of 6-Mercaptopurine Anticancer Drug

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dc.authoridKarimi-Maleh, Hassan/0000-0002-1027-481X
dc.authoridEnsafi, Ali A./0000-0002-1193-4090
dc.authoridAtar, Necip/0000-0001-8779-1412
dc.contributor.authorKarimi-Maleh, Hassan
dc.contributor.authorTahernejad-Javazmi, Fahimeh
dc.contributor.authorAtar, Necip
dc.contributor.authorLutfi, Mehmet
dc.contributor.authorGupta, Vinod Kumar
dc.contributor.authorEnsafi, Ali A.
dc.date.accessioned2025-03-23T19:35:49Z
dc.date.available2025-03-23T19:35:49Z
dc.date.issued2015
dc.departmentSinop Üniversitesi
dc.description.abstractA novel and sensitive biosensor employing immobilized DNA on a pencil graphite electrode modified with polypyrrole/functionalized multiwalled carbon nanotubes for the determination of 6-mercaptopurine (6-MP) is presented. In the first step, we modified the pencil graphite surface with polypyrrole and functionalized multiwalled carbon nanotubes (MWCNT/COOH). The developed electrode was characterized by scanning electron microscopy, atomic force microscopy, reflectionabsorption infrared spectroscopy, X-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy. In the other step, we used decreases in the oxidation responses of guanine and adenine as a sign of the interaction of 6-MP with salmon sperm double-stranded DNA using differential pulse voltammetry. The signal of guanine oxidation was linear with respect to the 6-MP concentration in the range of 0.2-100 mu mol L-1 with a detection limit of 0.08 mu mol L-1. The modified electrode was utilized for the determination of 6-MP in real samples.
dc.identifier.doi10.1021/ie504438z
dc.identifier.endpage3639
dc.identifier.issn0888-5885
dc.identifier.issue14
dc.identifier.scopus2-s2.0-84927944336
dc.identifier.scopusqualityQ1
dc.identifier.startpage3634
dc.identifier.urihttps://doi.org/10.1021/ie504438z
dc.identifier.urihttps://hdl.handle.net/11486/5940
dc.identifier.volume54
dc.identifier.wosWOS:000353177800012
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofIndustrial & Engineering Chemistry Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectSensitive Voltammetric Sensor
dc.subjectPaste Electrode
dc.subjectNanoparticles
dc.subjectNanocomposite
dc.subjectGlutathione
dc.subjectQuercetin
dc.titleA Novel DNA Biosensor Based on a Pencil Graphite Electrode Modified with Polypyrrole/Functionalized Multiwalled Carbon Nanotubes for Determination of 6-Mercaptopurine Anticancer Drug
dc.typeArticle

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