Novel Benzimidazole- Platinum(II) Complexes: Synthesis, Characterization, Antimicrobial and Anticancer Activity
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Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Three new Platinum complexes (1-3) with 2,6-di-tert-butyl-4-(1-phenyl-1H-benzimidazol-2-yl) phenol (L-1), N, N-dimethyl-4-(1-phenyl-1H-benzimidazol-2-yl) aniline (L-2) and 4-(1H-benzimidazol-2-yl)-N, N-dimethylaniline (L-3) were prepared and characterized by FT-IR, NMR and Elemental analyses. The crystal structures of L-1, 1 and geometrical isomer of 1 (1a) were determined by X-Ray crystallography. The cytotoxic activities of the compounds were tested on against SHSY-5Y and U-87 cell lines. The antimicrobial evaluations of the compounds showed that they have a moderate antimicrobial effect on gram positive and gram negative bacteria. (C) 2020 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Benzimidazole, Benzimidazole platinum (II) complexes, Cytotoxicity, Antimicrobial activity
Kaynak
Journal of Molecular Structure
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
1229
