Tetrachloromethane Induced Acute Liver Injury in Mice: Biochemical and Histopathological Study of the Hepatoprotective Effect of Hep-X Standardized Botanical Dietary Supplement

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dc.authoridGUNER, ADEM/0000-0003-3295-3538
dc.authoridKarabay Yavasoglu, N.Ulku/0000-0002-7483-0184
dc.contributor.authorKarayildirim, Cinel Koksal
dc.contributor.authorGuner, Adem
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorInce, Iskender
dc.contributor.authorYasar, Mustafa
dc.contributor.authorYavasoglu, Nefise Ulku Karabay
dc.contributor.authorYavasoglu, Altug
dc.date.accessioned2025-03-23T19:44:07Z
dc.date.available2025-03-23T19:44:07Z
dc.date.issued2023
dc.departmentSinop Üniversitesi
dc.description.abstractThis work was aimed at investigating the hepatoprotective effect of Hep-X, a polyherbal formulation containing Silybum marianum L. (Milk thistle), Rosmarinus officinalis L. (Rosemary), Curcuma longa L. (Turmeric) and Fumaria officinalis L. (Fumitory) as standardized botanical dietary supplement, on mice with CCl4-induced acute liver injury. The total phenolic and flavonoid contents of Hep-X were determined as 0.125 and 0.528 mg/mL, respectively. The quercetin content was determined as 50 mu g/mL using HPLC analysis. The total antioxidant capacity showed correlation between the Hep-X concentration and percentage inhibition of free radicals. Hep-X was administered orally at 25, 50 and 100 mg/kg b.w./day against CCl4-induced hepatotoxicity in mice. The hepatic damage was measured using blood biochemical parameters. Animals upon Hep-X treatment exhibited better drug effIcacy in certain blood parameters than silymarin-treated mice. Also, Hep-X administration significantly ameliorated the liver damage by suppressing iNOS expression and apoptosis as well as by recovery of the histological structure. The obtained results suggest that Hep-X is able to significantly alleviate the hepatotoxicity induced by CCl4 in mice, which can be due to antioxidant properties of the polyherbal formulation.
dc.description.sponsorshipNaturin Nutraceuticals Products Company Izmir, Turkey; Ege University, Faculty of Science [2012/ILAM/002]
dc.description.sponsorshipThis study was supported by the Naturin Nutraceuticals Products Company Izmir, Turkey and Ege University, Faculty of Science (Project Number 2012/ILAM/002)
dc.identifier.doi10.1007/s11094-023-02839-8
dc.identifier.endpage1649
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue12
dc.identifier.scopus2-s2.0-85150372380
dc.identifier.scopusqualityQ4
dc.identifier.startpage1639
dc.identifier.urihttps://doi.org/10.1007/s11094-023-02839-8
dc.identifier.urihttps://hdl.handle.net/11486/6875
dc.identifier.volume56
dc.identifier.wosWOS:000953858800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPharmaceutical Chemistry Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectCCl4-induced acute liver injury
dc.subjectHep-X polyherbal formulation
dc.subjectbotanical dietary supplement
dc.subjectprotective effect
dc.subjecthistochemistry
dc.subjectimmunohistochemistry
dc.titleTetrachloromethane Induced Acute Liver Injury in Mice: Biochemical and Histopathological Study of the Hepatoprotective Effect of Hep-X Standardized Botanical Dietary Supplement
dc.typeArticle

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