The Amyloid Beta Aggregation Inhibition Properties of New Pt (II) Complexes and Their Potential in Alzheimer's Treatment

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dc.contributor.authorGunnaz, Salih
dc.contributor.authorSahin, Onur
dc.contributor.authorIrisli, Sevil
dc.date.accessioned2026-04-25T14:18:57Z
dc.date.available2026-04-25T14:18:57Z
dc.date.issued2025
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, N-phenylortho-phenylenediamine and N-phenyl ethylenediamine were utilized as amines, and two novel ligands, benzimidazole (LI) and Schiff base (LII), were synthesized through condensation reactions with 3-methoxy-4-benzyloxybenzaldehyde. Furthermore, using these same amines, LIII (benzimidazole) with 3-phenoxybenzaldehyde and LIV (Schiff base) with 4-benzyloxybenzaldehyde were synthesized in accordance with the literature. Then, Pt (II) complexes (Ia, Ib, II, III, and IV) were prepared with these ligands, and it was determined that Ia and Ib are geometric isomers. The ligands and complexes were characterized using 1H-NMR, 13C-NMR, FT-IR, and elemental analysis methods. The cytotoxic effects of these complexes were evaluated on SH-SY5Y neuronal cells. Low-toxicity complexes Ia, II, and IV were then tested for their ability to inhibit amyloid beta (A beta 1-42) aggregation. Thioflavin T fluorescence analysis, AFM imaging, and MALDI-TOF mass spectrometry demonstrated that these complexes, particularly at a 1:1 complex-to-amyloid molar ratio, effectively inhibited A beta aggregation. These findings suggest that Pt (II) complexes containing Schiff base and benzimidazole ligands may be effective against Alzheimer's disease by alleviating A beta toxicity.
dc.description.sponsorshipIYTE National Mass Spectrometry Application
dc.description.sponsorshipWe would like to thank Ege University, MATAL Center for cytotoxicity measurements, and the IYTE National Mass Spectrometry Application and Research Center for MALDI/TOF MS measurements.
dc.identifier.doi10.1002/aoc.70159
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue5
dc.identifier.scopus2-s2.0-105002231104
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/aoc.70159
dc.identifier.urihttps://hdl.handle.net/11486/8126
dc.identifier.volume39
dc.identifier.wosWOS:001477850300003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofApplied Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260420
dc.subjectanti-Alzheimer activity
dc.subjectbenzimidazole
dc.subjectplatinum complexes
dc.subjectSchiff base
dc.titleThe Amyloid Beta Aggregation Inhibition Properties of New Pt (II) Complexes and Their Potential in Alzheimer's Treatment
dc.typeArticle

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