Novel diamide derivatives: Synthesis, characterization, urease inhibition, antioxidant, antibacterial, and molecular docking studies
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Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Novel diamides ( I -VI ) were synthesized, corroborated by various spectroscopic techniques including IR, H-1 NMR, C-13 NMR, mass spectrophotometry and elemental analysis. The in vitro screening of the newly synthesized compounds was evaluated for their urease inhibition activity and compound IV was found the most potent derivative with 2.5-fold more enhanced activity (IC50 = 8.17 +/- 0.39 mg/mL) than the standard drug thiourea (IC50 = 20.79 +/- 0.34 mg/mL). The molecular docking study supported the experimental results and revealed that compound IV has shown a significant dock score and binds within the active site of the target enzyme. Furthermore, these compounds were investigated for their efficacy as antioxidant and antimicrobial agents in vitro. Among all the tested compounds, compound I (IC50 = 45.88 perpendicular to 3.99 mu g/mL) showed the highest antioxidant activity, whereas compound VI (IC50 = 124.60 perpendicular to 2.20 mu g/mL) exhibited the lowest activity when compared to standards. Concerning antibacterial activities especially compound III showed superior antimicrobial activity against the bacteria type B. cereus compared to the other compounds. Based on the present research, it was concluded that useful application areas such as the pharmaceutical industry can be investigated by conducting in vivo biochemical tests of effective diamides. (c) 2022 Published by Elsevier B.V.
Açıklama
Anahtar Kelimeler
Diamide, Acylation template, Molecular docking, Urease inhibition, Biological activity, Spectroscopic elucidation
Kaynak
Journal of Molecular Structure
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
1261
