Association between family history of premature coronary artery disease and coronary atherosclerotic plaques shown by multidetector computed tomography coronary angiography

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dc.authoridOto, Sibel/0000-0003-0171-4200
dc.authoridCanpolat, Ugur/0000-0002-4250-1706
dc.contributor.authorSunman, Hamza
dc.contributor.authorYorgun, Hikmet
dc.contributor.authorCanpolat, Ugur
dc.contributor.authorHazirolan, Tuncay
dc.contributor.authorKaya, Ergun Baris
dc.contributor.authorAtes, Ahmet Hakan
dc.contributor.authorDural, Muhammed
dc.date.accessioned2025-03-23T19:41:28Z
dc.date.available2025-03-23T19:41:28Z
dc.date.issued2013
dc.departmentSinop Üniversitesi
dc.description.abstractBackground: There is controversy regarding the role of family history (FH) of premature coronary artery disease (CAD) as an independent risk factor for CAD. Herein, we aimed to assess the role of FH of premature CAD in prediction of coronary atherosclerosis shown by multidetector computed tomography (MDCT) coronary angiography. Methods: We analyzed consecutive subset of 349 patients in whom MDCT coronary angiography was performed for suspected CAD. All patients underwent coronary MDCT imaging using dual-source MDCT scanner. Coronary arteries were evaluated on 16-segment basis, critical CAP was described as luminal narrowing >50%, whereas plaque morphology was assessed on per segment basis. Results: Study population consisted of 202 (57.9%) male and 147 (42.1%) female patients with mean age of 57.8 +/- 10.8 years. The presence of CAP was higher in patients with FH of premature CAD in LAD and Cx compared to patients without FH of premature CAD (70.8% vs 58.0%, p=0.013 for LAD; 42.3% vs 30.4%, p=0.021 for Cx; 34.5% vs 29.8%, p=0.348 for RCA). In multinominal logistic regression analysis age, male gender, dyslipidemia and FH of premature CAD seemed significant predictors of primarily noncalcified CAP(OR:1.17, 95% CI:1.07-1.15, p<0.001; OR:0.19, 95% CI:0.09-0.38, p<0.001; OR:2.26, 95% CI:1.21-4.24, p=0.01; OR:3.32, 95% CI:1.74-6.34, p<0.001 respectively) after adjustment for other risk factors. Conclusion: Our study results indicate that FH of premature CAD is associated with severity, extent and noncalcified CAP shown by MDCT. Further investigation is needed to clarify the exact diagnostic and prognostic role of MDCT coronary angiography in subjects with positive FH and suspected CAD. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.doi10.1016/j.ijcard.2011.07.043
dc.identifier.endpage358
dc.identifier.issn0167-5273
dc.identifier.issue3
dc.identifier.pmid21807431
dc.identifier.scopusqualityQ1
dc.identifier.startpage355
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2011.07.043
dc.identifier.urihttps://hdl.handle.net/11486/6591
dc.identifier.volume164
dc.identifier.wosWOS:000316599700025
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofInternational Journal of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectFamily history
dc.subjectCoronary atherosclerotic plaque
dc.subjectMultidetector computerized tomography
dc.titleAssociation between family history of premature coronary artery disease and coronary atherosclerotic plaques shown by multidetector computed tomography coronary angiography
dc.typeArticle

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