Synthesis and biological evaluation of a novel ONS tridentate Schiff base bearing pyrimidine ring and some metal complexes

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dc.contributor.authorSonmez, Mehmet
dc.contributor.authorSogukomerogullari, Hatice Gamze
dc.contributor.authorOztemel, Feyza
dc.contributor.authorBerber, Ismet
dc.date.accessioned2025-03-23T19:44:44Z
dc.date.available2025-03-23T19:44:44Z
dc.date.issued2014
dc.departmentSinop Üniversitesi
dc.description.abstractThe new Schiff base ligand (1-[[1-(5-chloro-2-hydroxyphenyl)ethyliden]amino]-4-phenyl-5-benzoyl-pyrimidine-2-thione) and its Cu(II), Co(II), Pd(II), and Mn(II) complexes were synthesized and characterized by elemental and molar conductance, UV-Vis, IR, NMR spectra, magnetic moment as well as mass spectra. While Pd(II) complexes exhibited square planar geometry, the others displayed octahedral geometry. The complexes showed nonelectrolytic behavior. All the compounds were evaluated for in vitro antimicrobial efficiency against Gram-positive bacteria, Gram-negative bacteria, and yeast using microdilution procedure. This study suggested that the [Co(L)(2)]center dot 3H(2)O (1b) and [Mn(L)(2)]center dot 2H(2)O (1d) complexes might be new potential antimicrobial substances against bacteria and fungi.
dc.description.sponsorshipPresidency of Scientific Research Projects of University Gaziantep [FEF-10-09]
dc.description.sponsorshipWe are grateful to Presidency of Scientific Research Projects of University Gaziantep (FEF-10-09) for the support of this research.
dc.identifier.doi10.1007/s00044-014-0925-0
dc.identifier.endpage3457
dc.identifier.issn1054-2523
dc.identifier.issn1554-8120
dc.identifier.issue7
dc.identifier.scopus2-s2.0-84902382919
dc.identifier.scopusqualityQ1
dc.identifier.startpage3451
dc.identifier.urihttps://doi.org/10.1007/s00044-014-0925-0
dc.identifier.urihttps://hdl.handle.net/11486/7009
dc.identifier.volume23
dc.identifier.wosWOS:000336742500017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer Birkhauser
dc.relation.ispartofMedicinal Chemistry Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectPyrimidine-2-thione
dc.subject5-Chloro-2-hydroxyacethophenone
dc.subjectSchiff base metal complexes
dc.subjectBiological studies
dc.titleSynthesis and biological evaluation of a novel ONS tridentate Schiff base bearing pyrimidine ring and some metal complexes
dc.typeArticle

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