Synthesis, crystal structure, spectroscopy, thermal properties and carbonic anhydrase activities of new metal(II) complexes with mefenamic acid and picoline derivatives

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dc.authoridDilek, Esra/0000-0002-3629-5168
dc.contributor.authorDilek, Esra
dc.contributor.authorCaglar, Sema
dc.contributor.authorDogancay, Nesrin
dc.contributor.authorCaglar, Bulent
dc.contributor.authorSahin, Onur
dc.contributor.authorTabak, Ahmet
dc.date.accessioned2025-03-23T19:35:25Z
dc.date.available2025-03-23T19:35:25Z
dc.date.issued2017
dc.departmentSinop Üniversitesi
dc.description.abstractThe mononuclear six metal(II) complexes ([Co(mef)(2)(3-pic)(2)(CH3OH)(2)] (1), [Ni(mef)(2)(3-pic)(2)(CH3OH)(2)] (2), [Cu(mef)(2)(3-pic)(2)] (3), [Co(mef)(2)(4-pic)(2)] (4), [Ni(mef)(2)(4-pic)(2)] (5), and [Cu(mef)(2)(4-pic)(2)] (6) with mefenamic acid and picoline ligands were synthesized, characterized, and their carbonic anhydrase inhibitory activities were evaluated. The six complexes were characterized by elemental analysis, FT-IR spectroscopy, and thermal analyses. The crystal structures of 1, 3, and 6 were determined by X-ray crystallography. The complexes have octahedral geometry. In 1, the mefenamato ligand behaved as monodentate whereas in 3 and 6, the mefenamato ligand acted as a bidentate ligand. Complexes 3 and 6 consist of the mefenamate and 4-picoline ligands. In 1, unlike the other complexes, methanol acted as a ligand and was involved in the coordination. Carbonic anhydrase I and II isoenzymes were purified from human erythrocytes. The in vitro effects of mefenamic acid, 3-picoline, 4-picoline, and the six metal(II) complexes on these isoenzymes were evaluated. [GRAPHICS]
dc.description.sponsorshipResearch Foundation of Erzincan University [FYL-2017-446]
dc.description.sponsorshipThis work was supported by Research Foundation of Erzincan University [grant number FYL-2017-446].
dc.identifier.doi10.1080/00958972.2017.1366996
dc.identifier.endpage2852
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue16
dc.identifier.scopus2-s2.0-85028539012
dc.identifier.scopusqualityQ3
dc.identifier.startpage2833
dc.identifier.urihttps://doi.org/10.1080/00958972.2017.1366996
dc.identifier.urihttps://hdl.handle.net/11486/5867
dc.identifier.volume70
dc.identifier.wosWOS:000410928300006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Coordination Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectMefenamic acid
dc.subjectpicoline
dc.subjectmetal complex
dc.subjectcarbonic anhydrases
dc.titleSynthesis, crystal structure, spectroscopy, thermal properties and carbonic anhydrase activities of new metal(II) complexes with mefenamic acid and picoline derivatives
dc.typeArticle

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