a-Glucosidase inhibition properties of novel azaphthalocyanines containing vanillin

Basit Öğe Kaydı
dc.contributor.authorKantar, Guenay Kaya
dc.contributor.authorBalta, Nimet
dc.contributor.authorSahin, Onur
dc.contributor.authorSasmaz, Selami
dc.date.accessioned2025-03-23T19:25:34Z
dc.date.available2025-03-23T19:25:34Z
dc.date.issued2023
dc.departmentSinop Üniversitesi
dc.description.abstractVanillin substituted novel zinc(II) azaphthalocyanines (ZnAzaPcs) have been synthesized and investigated for their & alpha;-glucosidase inhibition properties. The new compounds (1, 2, 1a and 2a) have been characterised using a combination of FT-IR, 1H and 13C NMR, UV-Vis, MS and elemental analysis. The crystal structures of starting pyrazine compounds 1 and 2 have also been determined by the single crystal diffraction technique. All newly synthesized compounds have been evaluated for their in vitro inhibitory activity against a-glucosidase and all of them have more inhibitory effect when compared to acarbose as reference compound. Especially, compound 2 shows the most significant a-glucosidase inhibition. IC50 values of compound 2 and acarbose, which is known as & alpha;-glucosidase inhibitor used as anti-diabetic drug, have been found to be 6.01 & PLUSMN;0.16 and 9.52 & PLUSMN;0.23 & mu;g/mL, respectively.
dc.identifier.doi10.56042/ijc.v62i7.3730
dc.identifier.endpage734
dc.identifier.issn0019-5103
dc.identifier.issue7
dc.identifier.scopus2-s2.0-85169574705
dc.identifier.scopusqualityN/A
dc.identifier.startpage728
dc.identifier.urihttps://doi.org/10.56042/ijc.v62i7.3730
dc.identifier.urihttps://hdl.handle.net/11486/4502
dc.identifier.volume62
dc.identifier.wosWOS:001038274800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherNatl Inst Science Communication & Policy Research-Niscpr
dc.relation.ispartofIndian Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250323
dc.subjectAzaphthalocyanine
dc.subjectVanillin
dc.subjecta-Glucosidase inhibition
dc.titlea-Glucosidase inhibition properties of novel azaphthalocyanines containing vanillin
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu