Iron(III) and nickel(II) complexes with S-alkyl (n-C1-6)-thiosemicarbazidato ligands: Synthesis, structural characterization, and antioxidant features

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dc.authoridBener, Mustafa/0000-0002-2699-1354
dc.authoridKaya, Busra/0000-0003-2706-172X
dc.authoridULKUSEVEN, BAHRI/0000-0001-6342-1505
dc.contributor.authorKaya, Busra
dc.contributor.authorSahin, Onur
dc.contributor.authorBener, Mustafa
dc.contributor.authorUlkuseven, Bahri
dc.date.accessioned2025-03-23T19:39:36Z
dc.date.available2025-03-23T19:39:36Z
dc.date.issued2018
dc.departmentSinop Üniversitesi
dc.description.abstractSix of acetylacetone-S-R-thiosemicarbazones (R: methyl, ethyl, propyl, butyl, pentyl or hexyl) were synthesized, and the template reactions resulting in N2O2 type complexes of the thiosemicarbazones with 4-methoxy-salicylaldehyde were carried out in the presence of iron(III) or nickel(II). The thiosemicarbazones and metal complexes were defined by elemental analysis, and infrared, UV-Vis, H-1 NMR spectra. Three complexes bearing butyl-pentyl- and hexyl-groups were analyzed by X-Ray diffraction technique. The crystal data demonstrated that the iron complexes are in square pyramidal structure and nickel complexes in square planar structure. To explicate the relationship between the S-alkyl chain length and antioxidant ability, total antioxidant capacity (as TEAC value) and free radical scavenging activity of the compounds have been tested using CUPRAC and DPPH methods, respectively. Furthermore, the antioxidant potential of the thiosemicarbazones were determined in vitro measuring the scavenging activity of hydroxyl radical (center dot OH), superoxide anion radical (center dot O-2(-)), and hydrogen peroxide (H2O2). The results revealed that the compounds have an antioxidant features comparable to ascorbic acid reference. Synthesized compounds with the remarkable antioxidant properties have a potential to examine in development of new anticancer agents. (C) 2018 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [22167]
dc.description.sponsorshipThis work was supported by the Scientific Research Projects Coordination Unit of Istanbul University (Project Number: 22167). The authors acknowledge Scientific and Technological Research Application and Research Center, Sinop University, Turkey, for the use of the Bruker D8 QUEST diffractometer.
dc.identifier.doi10.1016/j.molstruc.2018.04.082
dc.identifier.endpage22
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85047435629
dc.identifier.scopusqualityQ1
dc.identifier.startpage16
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2018.04.082
dc.identifier.urihttps://hdl.handle.net/11486/6382
dc.identifier.volume1167
dc.identifier.wosWOS:000435052300003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectThiosemicarbazone
dc.subjectMetal complex
dc.subjectStructural analysis
dc.subjectAntioxidant capacity
dc.subjectRadical scavenging activity
dc.titleIron(III) and nickel(II) complexes with S-alkyl (n-C1-6)-thiosemicarbazidato ligands: Synthesis, structural characterization, and antioxidant features
dc.typeArticle

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