Synthesis, structural, thermal elucidation and in vitro anticancer activity of novel silver(I) complexes with non-steroidal anti-inflammatory drugs diclofenac and mefenamic acid including picoline derivatives

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dc.contributor.authorAltay, Ahmet
dc.contributor.authorCaglar, Sema
dc.contributor.authorCaglar, Bulent
dc.contributor.authorSahin, Onur
dc.date.accessioned2025-03-23T19:38:19Z
dc.date.available2025-03-23T19:38:19Z
dc.date.issued2018
dc.departmentSinop Üniversitesi
dc.description.abstractSix new Ag(I) coordination complexes, namely [Ag-4(mu-dicl)(4)(2-pic)(3)] 1, [Ag-2(mu-mef)(2)(2-pic)(2)] 2, [Ag-2(mu-dicl)(2)(3-pic)(2)] 3, [Ag-2(mu-mef)(2)(3-pic)(2)] 4, [Ag-2(mu-dicl)(2)(4-pic)(2)] 5 and [Ag-2(mu-mef)(2)(4-pic)(2)] 6, were synthesized and characterized by elemental analysis, FT-IR and thermal analysis techniques. The crystal structures of 1, 3, 4 and 5 were determined by X-ray diffraction analysis, whereas 2 and 6 were obtained as microcrystalline powders. X-ray diffraction analysis demonstrated that 1 occurs as a tetranuclear complex, while 3, 4 and 5 have binuclear structures. A short Ag center dot center dot center dot Ag distances of 2.8446 and 2.8823 angstrom for 1, 2.8409 angstrom for 3, 2.8942 angstrom for 4 and 2.8423 angstrom for 5 were found in the complexes, indicating that argentophilic interactions exist between the silver ions. In 1, the dicl ligands act as mu(3)-O,O',O' bridging ligands between three Ag(I) ions. In 3, 4 and 5, the dicl and mef ligands behave as bridging ligands and bind two Ag(I) ions together with the carboxylato oxygen atoms. The simultaneous TG/DTG and DTA techniques were applied to interpret the mass losses, decomposition temperatures and corresponding processes of the thermal behaviours of the complexes. The experimental and calculated mass losses of the proposed structures for complexes 2 and 6 are quite compatible with each other and these complexes have very similar FT-IR spectra to the other complexes, which reflect their same structural geometries and characteristics. The cytotoxic activities of the complexes (16) were tested against three different cancer cell lines, MCF-7, HT-29 and HepG2, and one normal cell line, 3 T3-L1. XTT assay results demonstrated that although all the silver(I) complexes showed good cytotoxic activity, depending on the cell types tested, the complexes with mefanamic acid (2, 4 and 6) were found to predominate over those with diclofenac (1, 3 and 5), as well as the superiority of 3-picoline to 4-picoline and 2-picoline. Moreover, compared with the cytotoxic potential of carboplatin, 4 especially exhibited a significant cancer cell inhibitory rate and lower cytotoxicity toward the normal cell line, with much higher selectivity indexes. (C) 2018 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.poly.2018.05.038
dc.identifier.endpage170
dc.identifier.issn0277-5387
dc.identifier.scopus2-s2.0-85047825401
dc.identifier.scopusqualityQ2
dc.identifier.startpage160
dc.identifier.urihttps://doi.org/10.1016/j.poly.2018.05.038
dc.identifier.urihttps://hdl.handle.net/11486/6123
dc.identifier.volume151
dc.identifier.wosWOS:000440125700018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPolyhedron
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectDiclofenac
dc.subjectMefenamic acid
dc.subjectSilver(I) complexes
dc.subjectCell culture
dc.subjectCytotoxicity
dc.titleSynthesis, structural, thermal elucidation and in vitro anticancer activity of novel silver(I) complexes with non-steroidal anti-inflammatory drugs diclofenac and mefenamic acid including picoline derivatives
dc.typeArticle

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