A novel 1D borotungstate polymer: Structure and biologic activity

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dc.contributor.authorCakar, Afife Banu
dc.contributor.authorCakir, Mucahit Suleyman
dc.contributor.authorBesli, Erdem
dc.contributor.authorColak, Ferdag
dc.contributor.authorIca, Tuba
dc.contributor.authorSahin, Onur
dc.contributor.authorDikim, Selinsu
dc.date.accessioned2026-04-25T14:19:58Z
dc.date.available2026-04-25T14:19:58Z
dc.date.issued2026
dc.departmentSinop Üniversitesi
dc.description.abstractIn this study, a novel boron-containing polyoxometalate (BPOM) coordination polymer, Na5[trea]3[BW12O40]& sdot; 3H2O (Compound 1; trea = triethylamine), with a molecular weight of 3329.57 g/mol, was synthesized and comprehensively characterized by elemental analysis, single-crystal X-ray diffraction, NMR and FT-IR spectroscopy. Antimicrobial assays demonstrated that Compound 1 exhibited MIC values ranging from 62.5-1000 mu g/mL (1.88x10-5-3.00x10-4 M) for Gram-positive strains and 3.9-62.5 mu g/mL (1.17x10-6-1.88x10-5 M) for Gram-negative strains. The strongest inhibition was observed against Arcobacter butzleri AB5 with a MIC of 3.9 mu g/mL (1.17x10-6 M) and MBC of 7.18 mu g/mL (2.15x10-6 M). For Staphylococcus aureus ATCC 29213, MIC and MBC were 62.5 mu g/mL (1.88x10-5 M) and 250 mu g/mL (7.51x10-5 M), respectively. For Listeria monocytogenes, MIC values were 250-1000 mu g/mL (7.51x10-5-3.00x10-4 M). Antibiofilm testing using a virulent Escherichia coli wild-type strain revealed a concentration-dependent inhibition, with 72% biofilm reduction at 1000 mu g/mL (3.00x10-4 M) and 60%, 56%, 48%, 37%, and 21% reduction at 500, 250, 125, 62.5 and 31.2 mu g/mL, respectively. Haemolysis assays showed 0% erythrocyte lysis up to 1000 mu g/mL, indicating non-toxic behavior toward red blood cells. DNA interaction experiments using pBR322 plasmid DNA demonstrated no conversion of supercoiled Form Ito nicked (Form II) or linear DNA (Form III) at 1000 mu g/mL (3.00x10-4 M) or 500 mu g/mL (1.50x10-4 M) after 4 h incubation at 37 degrees C, indicating absence of DNA cleavage activity. These data position boron-substituted polyoxometalates as promising antimicrobial and antibiofilm candidates with clearly defined quantitative performance parameters.
dc.identifier.doi10.1016/j.molstruc.2025.145213
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-105027183064
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2025.145213
dc.identifier.urihttps://hdl.handle.net/11486/8296
dc.identifier.volume1357
dc.identifier.wosWOS:001661712800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260420
dc.subjectAntibiofilm activity
dc.subjectAntimicrobial activity
dc.subjectBorotungstate
dc.subjectDNA cleavage
dc.subjectPolyoxometalates
dc.subjectSingle crystal
dc.titleA novel 1D borotungstate polymer: Structure and biologic activity
dc.typeArticle

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