Synthesis, characterization, cyclic voltammetry, and antimicrobial properties of N-(5-benzoyl-2-oxo-4-phenyl-2H-pyrimidine-1-yl)-malonamic acid and its metal complexes

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dc.authoridCELEBI, METIN/0000-0003-1475-8878
dc.authoridSenturk, Zuhre/0000-0002-0356-9345
dc.authoridLevent, Abdulkadir/0000-0001-5792-419X
dc.contributor.authorSonmez, Mehmet
dc.contributor.authorCelebi, Metin
dc.contributor.authorLevent, Abdulkadir
dc.contributor.authorBerber, Ismet
dc.contributor.authorSenturk, Zuehre
dc.date.accessioned2025-03-23T19:35:27Z
dc.date.available2025-03-23T19:35:27Z
dc.date.issued2010
dc.departmentSinop Üniversitesi
dc.description.abstractA new heterocyclic compound, N-(5-benzoyl-2-oxo-4-phenyl-2H-pyrimidin-1-yl)-malonamic acid, was synthesized from N-aminopyrimidine-2-one and malonyldichloride. Bis-chelate complexes of the ligand were prepared from acetate/chloride salts of Cu(II), Co(II), Ni(II), Mn(II), Zn(II), Cd(II), Fe(III), Cr(III), and Ru(III) in methanol. The structures of the ligand and its metal complexes were characterized by microanalyses, IR, NMR, API-ES, UV-Vis spectroscopy, magnetic susceptibility, and conductometric analyses. Octahedral geometry was suggested for all the complexes, in which the metal center coordinates to ONO donors of the ligand. Each ligand binds the metal using C=O, HN, and carboxylate. The cyclic voltammograms of the ligand and the complexes were also discussed. The compounds were evaluated for their antimicrobial activities against Gram-positive and Gram-negative bacteria, and fungi using microdilution procedure. The antimicrobial studies showed that Cu(II), Fe(III), and Ru(III) complexes exhibited good antibacterial activity against Gram-positive bacteria with minimum inhibitory concentrations between 20 and 80 mu g mL-1. However, the ligand and the complexes possess weak efficacy against Gram-negative bacterium and Candida strains. As a result, we suggest that these complexes containing pyrimidine might be a new group of antibacterial agents against Gram-positive bacteria.
dc.description.sponsorshipScientific and Research Council of Turkey [TBAG 105T145]
dc.description.sponsorshipWe are grateful to Scientific and Research Council of Turkey (TBAG 105T145) for the support of this research.
dc.identifier.doi10.1080/00958972.2010.494252
dc.identifier.endpage2001
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue11
dc.identifier.scopus2-s2.0-77956300270
dc.identifier.scopusqualityQ3
dc.identifier.startpage1986
dc.identifier.urihttps://doi.org/10.1080/00958972.2010.494252
dc.identifier.urihttps://hdl.handle.net/11486/5874
dc.identifier.volume63
dc.identifier.wosWOS:000279706500016
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Coordination Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectN-aminopyrimidine complexes
dc.subjectCyclic voltammetry
dc.subjectBiological activity
dc.titleSynthesis, characterization, cyclic voltammetry, and antimicrobial properties of N-(5-benzoyl-2-oxo-4-phenyl-2H-pyrimidine-1-yl)-malonamic acid and its metal complexes
dc.typeArticle

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