Synthesis, characterization, antioxidant, and antibacterial activities of new 2,3-dimethoxy and 3-acetoxy-2-methyl benzamides

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dc.authoridCAKMAK, Sukriye/0000-0002-2221-0098
dc.authoridYAKAN, HASAN/0000-0002-4428-4696
dc.contributor.authorYakan, Hasan
dc.contributor.authorCakmak, Sukriye
dc.contributor.authorKutuk, Halil
dc.contributor.authorYenigun, Semiha
dc.contributor.authorOzen, Tevfik
dc.date.accessioned2025-03-23T19:44:04Z
dc.date.available2025-03-23T19:44:04Z
dc.date.issued2020
dc.departmentSinop Üniversitesi
dc.description.abstractWe performed a series of novel benzamide compounds which were synthesized starting from 2,3-dimethoxybenzoic acid or 3-acetoxy-2-methylbenzoic acid and amine derivatives. All the obtained products were purified, and the analysis of these products was determined with IR, H-1 NMR, C-13 NMR spectroscopic, and elemental methods. The in vitro antioxidant activity of all the compounds was determined by total antioxidant, free radical scavenging, and metal chelating activity. Some of synthesized compounds showed more effective total antioxidant, free radical scavenging, and metal chelating activity compared with standards. One of the benzamide compounds has been shown to exhibit effective metal chelate activity. The new compounds were determined in vitro antibacterial activity against three gram-positive bacteria and three gram-negative bacteria and compared with two control drugs. Thus, by conducting in vivo biochemical tests of effective amides, researches can be carried out in different fields of application. Graphic abstract We performed a series of novel benzamide compounds which were synthesized, and the analysis of these products was determined with IR, H-1 NMR, C-13 NMR spectroscopic, and elemental methods. The in vitro antioxidant activity of all the compounds was determined by total antioxidant, free radical scavenging, and metal chelating activity. All the compounds were tested for their in vitro growth inhibitory activity against different bacteria.
dc.identifier.doi10.1007/s11164-020-04118-7
dc.identifier.endpage2787
dc.identifier.issn0922-6168
dc.identifier.issn1568-5675
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85081896667
dc.identifier.scopusqualityQ2
dc.identifier.startpage2767
dc.identifier.urihttps://doi.org/10.1007/s11164-020-04118-7
dc.identifier.urihttps://hdl.handle.net/11486/6862
dc.identifier.volume46
dc.identifier.wosWOS:000524572900019
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofResearch On Chemical Intermediates
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250323
dc.subjectAmides
dc.subjectN-acylation
dc.subjectMetal chelating activity
dc.subjectAntioxidant activity
dc.subjectAntibacterial activity
dc.subjectSpectroscopic techniques
dc.titleSynthesis, characterization, antioxidant, and antibacterial activities of new 2,3-dimethoxy and 3-acetoxy-2-methyl benzamides
dc.typeArticle

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